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Inflammatory Bowel Disease
Crossroads of Microbes, Epithelium and Immune Systems

Derek J. Chadwick (Edited by), Novartis (Author), Jamie A. Goode (Edited by)

9780470090466, Wiley

Hardback, published 12 November 2004

240 pages
23.6 x 16 x 1.7 cm, 0.508 kg

"This is a well written book that provides a succinct, easy to read summary of the current concepts in IBD. The discussions following each chapter are invaluable." (Doody's Book Review Service)

Inflammatory bowel disease (IBD) comprises a group of idiopathic diseases of the intestine characterized by chronic inflammation of the bowel with periods of exacerbation and remission. Although the exact cause of IBD remains undetermined, the condition appears to be related to a combination of genetic and environmental factors resulting in an aberrant activation of the mucosal immune system. This book contains a series of interdisciplinary discussions between clinical and basic scientists focusing on key issues such as: <>

  • Epithelial cell and molecular biology, including apoptosis, necrosis and cell survival
  • The role of bacterial milieu and mucosal bacteria in the IBD and of prebiotic and probiotic therapy
  • The progress towards the identification of susceptibility genes and phenotype-determining genes
  • The pharmacogenetics of IBD
  • Mucosal immunology and therapeutic strategies stemming therefrom

Symposium on Inflammatory bowel disease-crossroads of microbes, epithelium and immune systems, held at the Novartis Foundation, London, 25 - 27 November 2003

Editors: Derek Chadwick (Organizer) and Jamie Goode

This symposium is based on a proposal made by Derek Jewell and Bill Roediger

Derek Jewell Chair's introduction 1

John D. Rioux Progress towards identifying inflammatory bowel disease susceptibility genes 3
Discussion 11

T. Ahmad Phenotype-determining genes in inflammatory bowel disease 17
Discussion 29

Dermot Kelleher, Richard Farrell and Ross McManus Pharmacogenetics of inflammatory bowel disease 41
Discussion 53

G.T. Macfarlane, E. Furrie and S. Macfarlane Bacterial milieu and mucosal bacteria in ulcerative colitis 57
Discussion 64

Y. R. Mahida and R. N. Cunliffe Defensins and mucosal protection 71
Discussion 77

W. E.W. Roediger Intestinal mycoplasma in Crohn's disease 85
Discussion 93

John H. Cummings and San Choon Kong Probiotics, prebiotics and antibiotics in inflammatory bowel disease 99
Discussion 112

Andrei I. Ivanov, Asma Nusrat and Charles A. Parkos The epithelium in inflammatory bowel disease: potential role of endocytosis of junctional proteins in barrier disruption 115
Discussion 124

Peter R. Gibson Apoptosis or necrosis ö colonic epithelial cell survival 133
Discussion 145

Ken Takeuchi, Laurence Maiden and Ingvar Bjarnason Genetic aspects of intestinal permeability in inflammatory bowel disease 151
Discussion 159

Fiona Powrie and Holm Uhlig Animal models of intestinal inflammation: clues to the pathogenesis of inflammatory bowel disease 164
Discussion 174

Holm H. Uhlig, Christian Mottet and Fiona Powrie Homing of intestinal immune cells 179
Discussion 188

S. Ghosh Anti-TNF therapy in Crohn's disease 193
Discussion 205

Final discussion 211
Index of contributors 219
Subject index 221

Subject Areas: Biology, life sciences [PS]
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