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Immunotherapy in Transplantation
Principles and Practice
Bruce Kaplan (Edited by), Gilbert J. Burkhart (Edited by), Fadi G. Lakkis (Edited by)
9781405182713, Wiley
Hardback, published 13 April 2012
496 pages
24.4 x 19.7 x 2.8 cm, 0.998 kg
“Overall, the text is highly structured, well presented and applicable to transplant clinicians and pharmacologists in particular. . . . Those wishing to advance their understanding of transplant immunology, the technologies and techniques used for drug monitoring, the drug development pipeline and the basis for use of current agents in transplantation will find their interests more than satisfied.” (American Journal of Transplantation, 5 September 2013) “It will serve a clinician well as a focused reference for immunology and pharmacotherapy relevant to the transplant arena. It would be a welcome and useful addition to the medical or pharmaceutical library of a transplant professional or institution, albeit on the expensive side for a focused textbook.” (The Annals of Pharmacotherapy, 1 March 2013) “This comprehensive reference source will benefit all transplant specialists working with pharmacologic and biologic agents that modulate the immune system.” (European Journal of Immunology, 1 December 2012) “This is a decent review of transplant immunology that is helpful for the training practitioner. Given its systematic approach, it is easier to follow than other books on the subject.” (Doody’s, 17 August 2012)
Immunotherapy in Transplantation: Principles and Practice This comprehensive reference source will benefit all transplant specialists working with pharmacologic and biologic agents that modulate the immune system. Compiled by a team of world-renowned editors and contributors covering the fields of transplantation, nephrology, pharmacology, and immunology, the book covers all anti-rejection drugs according to a set template and includes the efficacy of each for specific diseases.
List of Contributors, vii Part 1 Transplantation Immunobiology 1 The Immune Response to a Transplanted Organ: An Overview, 3 2 Antigen Presentation in Transplantation, 10 3 The T Cell Response to Transplantation Antigens, 19 4 The B Cell Response to Transplantation Antigens, 38 5 The Innate Response to a Transplanted Organ, 54 6 Regulation of the Alloimmune Response, 62 Part 2 Transplantation Clinical Pharmacology 7 Pharmacokinetics, 81 8 Therapeutic Drug Monitoring for Immunosuppressive Agents, 95 9 Pharmacometrics: Concepts and Applications to Drug Development, 114 10 Pharmacogenomics and Organ Transplantation, 133 11 Study Design/Process of Development: Clinical Studies, 146 Part 3 Agents 12 Corticosteroids, 163 13 Azathioprine, 171 14 Pharmacokinetic and Pharmacodynamic Properties of Mycophenolate, 182 15 Cyclosporine: Molecular Action to Clinical Therapeutics, 197 16 Tacrolimus, 224 17 Inhibitors of Mammalian Target of Rapamycin, 241 18 Inhibitors Targeting JAK3, 273 19 Cyclophosphamide, 290 20 Application of Antisense Technology in Medicine, 296 21 The Role of Ganciclovir in Transplantation, 316 22 Transplantation Immunotherapy with Antithymocyte Globulin (ATG), 330 23 The Role of Alemtuzumab in Solid Organ Transplantation, 346 24 Rituximab, an Anti-CD20 Monoclonal Antibody, 362 25 The Anti-Interleukin 2 Receptor Antibodies, 378 26 Infliximab/Anti-TNF, 385 27 CTLA4-Ig, 399 28 Combination and Adjuvant Therapies to Facilitate the Efficacy of Costimulatory Blockade, 407 29 Intravenous Immunoglobulin (IVIG) a Modulator of Immunity and Inflammation with Applications in Solid Organ Transplantation, 429 Index, 447
Preface, xi
Fadi G. Lakkis
Martin H. Oberbarnscheidt and Fadi G. Lakkis
Didier A. Mandelbrot, Bryna Burrell, Mohamed H. Sayegh, and Peter S. Heeger
Roger Sciammas, Anita S. Chong, and Robert B. Colvin
Daniel R. Goldstein and Laurence A. Turka
Kathryn J. Wood and Terry B. Strom
Venkateswaran C. Pillai and Raman Venkataramanan
Michael C. Milone and Leslie M.J. Shaw
Mallika Lala and Jogarao V.S. Gobburu
Gilbert J. Burckart and Richard M. Watanabe
Richard D. Mamelok
Olivia R. Blume, Sarah E. Yost, and Bruce Kaplan
Barry J. Brown
David Hager, Arjang Djamali, and Bruce Kaplan
Bradford Strijack and Paul A. Keown
William E. Fitzsimmons
Barry D. Kahan
Gary Chan and Paul S. Changelian
John J. Curtis
Beata Mierzejewska and Stanislaw M. Stepkowski
Lyndsey J. Bowman and Daniel C. Brennan
John L. Dzuris, Christian Bloy, Melanie Ruzek, and John M. Williams
Avinash Agarwal, David Bruno, and Stuart J. Knechtle
Mark D. Pescovitz
Muna Alnimri and Flavio Vincenti
Marina Vardanyan, Edward C. Parkin, and Horacio L. Rodriguez Rilo
Sarah E. Yost and Bruce Kaplan
Swetha K. Srinivasan, Helen L. Triemer, and Allan D. Kirk
Stanley C. Jordan, Mieko Toyoda, Joseph Kahwaji, Alice Peng, and Ashley A. Vo
Color plates are found facing p. 213
Subject Areas: Clinical & internal medicine [MJ]
