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Immunotherapy in Translational Cancer Research
Laurence J. N. Cooper (Edited by), Elizabeth A. Mittendorf (Edited by), Judy Moyes (Edited by), Sabitha Prabhakaran (Edited by)
9781118123225, Wiley
Hardback, published 18 April 2018
312 pages
25.7 x 18.3 x 1.8 cm, 0.816 kg
A guide to state-of-the-art cancer immunotherapy in translational cancer research A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues. Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world’s foremost cancer research and care center and: Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.
Editors vi Contributors vii Introduction ix 1 Translation in Immunology: The Role of Translational Biomarkers to Guide Clinical Use of Immunotherapy for Cancer 1 2 Monoclonal Antibody Therapy 12 3 Somatic Mutations and Immunotherapy 24 4 Checkpoint Blockade 37 5 Myeloid Leukemia Vaccines 54 6 Cancer Vaccines for Solid Tumors 72 7 Immunotherapy with Non–Genetically Modified T Cells 91 8 Immunotherapy with Genetically Modified T Cells 101 9 Immunomodulation with Adjuvants and Cytokines 115 10 Immune Cell Migration in Cancer and Immunotherapy 132 11 Repurposing of Drugs for Immunotherapy 143 12 Immunomodulation with Radiation 161 13 Good Manufacturing Practices Facilities for Cellular Therapy 177 14 T Cell Receptor Mimic Antibodies 186 15 Stem Cell Transplantation for Treatment of Malignancy 201 16 Natural Killer Cell–Based Immunotherapy 215 17 Immunologic Monitoring in Immuno‐Oncology 228 18 Cell‐Based Therapies for Canine Cancer 252 19 Interaction between Targeted Therapy and Immunotherapy 268 Index 286
Saranya Chumsri and Keith L. Knutson
Elizabeth A. Mittendorf and Sabitha Prabhakaran
Eric Tran
Tracy A. Proverbs‐Singh Jedd Wolchok and Alexandra Snyder
Paul M. Armistead and Jonathan S. Serody
Timothy J. Vreeland Garth S. Herbert and George E. Peoples
Cassian Yee
Liora Schultz and Crystal Mackall
Dae won Kim and Adi Diab
Timothy Murray and Daniel E. Speiser
Jyothishmathi Swaminathan and Vidya Gopalakrishnan
Jonathan E. Schoenhals Taylor R. Cushman, Alexandra P. Cadena Sandra Demaria and James W. Welsh
Andrew D. Fesnak and Bruce L. Levine
Gheath Alatrash and Jeffrey J. Molldrem
Lohith S. Bachegowda and Richard E. Champlin
Jennifer A. Foltz Jeffrey S. Miller and Dean A. Lee
William R. Gwin and Mary L. Disis
Nicola J. Mason and M. Kazim Panjwani
Peter A. Prieto Miles C. Andrews, Alexandria P. Cogdill, and Jennifer A. Wargo
Subject Areas: Clinical & internal medicine [MJ]
