Immunological Aspects of the Vascular Endothelium

An 1995 look at the functioning of the vascular endothelium, and the diseases that arise as a result of inflammation and immunological responses.

Caroline O. S. Savage (Edited by), Jeremy D. Pearson (Edited by)

9780521452496, Cambridge University Press

Hardback, published 7 September 1995

276 pages
23.7 x 15.8 x 2.4 cm, 0.594 kg

"This is a stimulating monograph...recommended for readers interested in the endothelium and its rapid ascendance to the status of an immunologic organ." John A. Robinson, Doody's Health Sciences Book Review Journal

Originally published in 1995, this volume looks at the functioning of the vascular endothelium, and the diseases and tissue injury that arise as a result of inflammation and immunological responses. The vascular endothelium is a metabolically highly active layer of cells lining all blood vessel walls. Through its interactions with leucocytes and other mediators, it is central to the development of inflammatory foci and to lymphocyte trafficking around the body. Tissue injury may arise here as a result of abnormal inflammatory or immune responses. The potential for such injury to contribute to autoimmune disease is discussed in this book, particularly in relation to autoimmune vascular disease of the renal, rheumatological and neurological systems, as well as in organ transplantation.

1. New concepts of mechanisms in autoimmunity
2. Regulation of endothelial cell function by cytokines
3. Interactions between granulocytes and endothelium
4. The regulation of lymphocyte migration by vascular endothelium and its role in the immune response
5. The role of the vascular endothelium in immunologically-mediated neurological diseases
6. The role of the endothelium in systemic lupus erythematosus and Sjögren's syndrome
7. The role of the endothelium in rheumatoid arthritis and scleroderma
8. The role of the endothelium in systemic vasculitis
9. Endothelial involvement in childhood Kawasaki disease
10. The role of the endothelium in thrombotic thrombocytopaenic purpura and haemolytic uraemic sydrome
11. The immunological role of the endothelium in organ transplantation
Index.

Subject Areas: Immunology [MJCM]