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Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters
Concepts, Methods and Translational Sciences
A critical review of analytical technologies for detection and quantification of drugs, metabolites, and biomarkers
Shuguang Ma (Edited by), Swapan Chowdhury (Edited by)
9780128200186, Elsevier Science
Paperback, published 10 July 2020
708 pages, 120 illustrations (10 in full color)
23.4 x 19 x 4.3 cm, 1.46 kg
Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade’s numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism.
Part I: Techniques for Identifying and Quantifying Drugs and Metabolites 1. Bioanalysis of Small and Large Molecule Drugs, Metabolites, and Biomarkers by LC-MS 2. Recent advances in mass spectrometric and other analytical techniques for the identification of drug metabolites 3. High-resolution mass spectrometry-based data acquisition and data mining technologies for detecting and characterizing drug metabolites and herbal medicine components 4. Metabolite Generation and Metabolite Characterization by NMR 5. Application of SFC for bioanalysis 6. AMS in drug development: Exploring the current utility of AMS and future opportunities for Absolute Bioavailability and ADME investigations Part II: Drug Metabolism Enzymes, Transporters and Drug-Drug Interaction 7. Using in vitro methods to determine P450s responsible for metabolism and discrimination from other oxidative pathways 8. Evaluation of the clearance mechanism of non-CYP enzymes mediated drug metabolism and DDI as a victim drug 9. In vitro Characterization and In Vitro to In Vivo Predictions of Drug-Drug Interactions 10. Role of Transporters in drug disposition and Drug-drug Interactions 11. Mechanisms and Clinical Relevance of Pharmacokinetic-based Clinical Drug-drug Interactions for Drugs Recently Approved by the U.S. Food and Drug Administration 12. Quantifying drug metabolism enzymes and transporters by LC-MS/MS proteomics 13. Protein Drug-Drug Interactions for Disease Modifying Modalities Part III: Strategy Related to Drug Metabolism and Safety 14. Metabolites in safety testing (MIST) 15. The Use of Stable Isotopes in Drug Metabolism Studies 16. Assessment of Stereoselectivity in Pharmacology, Toxicology and Drug Metabolism 17. Progress of De-Risking Strategies for Drug-Induced Liver Injury (DILI) In the Last Two Decades 18. Predictive and Translational Models for Renal Drug Safety Evaluation 19. Immunogenicity: An Introduction to Its Role in the Safety and Efficacy of Biotherapeutics Part IV: Translational Sciences 20. Application of Genetically-Modified Rodent Models in Drug Discovery and Development for Translation of Clinical ADME Properties 21. Advances in CRISPR Technologies Enable Novel in vitro Tools for ADME Studies 22. In vitro-In vivo Extrapolation of Human Hepatic and Renal Clearance 23 The Role of Mathematical Modeling in Translational Science 24. PK/PD Driven Starting and Effective Human Dose Determination for Immuno-Oncology Drugs
