Hsp90 in Cancer: Beyond the Usual Suspects

The latest in the Advances in Cancer Research series provides the most up-to-date, invaluable information on the exciting and fast-moving field of cancer research, focusing mainly on the multifunctional molelcular chaperone Hsp90

Jennifer Isaacs (Volume editor), Luke Whitesell (Volume editor)

9780128022900

Hardback, published 25 February 2016

288 pages
22.9 x 15.1 x 2.3 cm, 0.63 kg

Praise for the Serial "This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences." --American Scientist "Excellent, highly informative, in-depth reviews…expertly written, up-to-date, and well-referenced." --Journal of Medicinal Chemistry "This is a series that has a long tradition of excellence in the field of cancer biology." --Doody’s Publishing Reviews

Hsp90 in Cancer: Beyond the Usual Suspects, the latest volume in the Advances in Cancer Research series, focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins and discusses some of the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression.

1. Unusual Suspects in the Twilight Zone between the Hsp90 Interactome and Carcinogenesis
Evangelia Vartholomaiou, Pablo C. Echeverría and Didier Picard
2. Impact of Post-translational Modifications on the Anticancer Activity of Hsp90 Inhibitors
Mark R. Woodford, Diana Dunn, Jonelle B. Miller,Sami Jamal, Len Neckers and Mehdi Mollapour
3. Anticancer Inhibitors of Hsp90 Function: Beyond the Usual Suspects
Gaurav Garg, Anuj Khandelwal and Brian S. J. Blagg
4. HSP90 in Cancer:  Transcriptional Roles in the Nucleus
S. K. Calderwood and L. Neckers
5. Hsp90 as a ‘Chaperone’ of the Epigenome: Insights and Opportunities for Cancer Therapy
Jennifer S. Isaacs
6. Emerging Roles of Extracellular Hsp90 in Cancer
Daniel Senh Wong and Daniel G. Jay
7. GRP94/gp96 in Cancer: Biology, Structure, Immunology and Drug Development
Bill X Wu, Feng Hong, Yongliang Zhang, Ephraim Ansa-Addo and Zihai Li
8. HSP90 and Immune Modulation in Cancer
Michael W. Graner
9. Hsp90: A Global Regulator of the Genotype-To-Phenotype Map in Cancers
Daniel Jarosz

Subject Areas: Cellular biology [cytology PSF], Molecular biology [PSD], Oncology [MJCL]