Homocysteine in Health and Disease

This is an unusually comprehensive 2001 account of the broad range of medical implications of homocysteine.

Ralph Carmel (Edited by), Donald W. Jacobsen (Edited by)

9781107402423, Cambridge University Press

Paperback / softback, published 21 July 2011

536 pages
27.9 x 21 x 2.7 cm, 1.19 kg

Review of the hardback: ' … a fascinating story, the authors are eminent in their fields and the coverage is authorititive and comprehensive. Here is an excellent reference book for anyone interested in the field. Given the important clinical, scientific, and policy issues raised by the folic acid association … geriatricians really need to know about homocysteine.' John Grimley Evans, Age and Aging

High levels of homocysteine have been identified as a very important risk factor in cardiovascular disease. Homocysteine-related abnormalities are also thought to contribute to birth defects and dementia, and there are many common acquired diseases, drugs and genetic disorders which adversely affect the metabolism of homocysteine. In this 2001 book a multidisciplinary team of experts in the field give a clear analysis of the biochemistry, genetics, epidemiology, clinical settings, causes, impact and treatment of homocysteine disorders. This is an unusually comprehensive account of the broad range of medical, nutritional and methodological implications of homocysteine in health and disease.

1. Introduction: historical overview and recent perspectives David Wilken and Bridget Wilken
Part I. Biochemistry and Physiology
Section I. Chemistry: 2. Practical chemistry of homocysteine and other thiols Donald W. Jacobsen
3. Biosynthesis and reactions of homocysteine thiolactone Hieronim Jakubowski
4. Homocysteine and lipid oxidation Jay W. Heinecke
5. Homocysteine, nitric oxide and nitrosothiols Andrew J. Gow, Fred Cobb and Jonathan S. Stamler
Section II. Biochemistry and metabolism: 6. Biosynthesis of S-adenosylmethionine Jose M. Mato, Matias A. Avila and Fernado J. Corrales
7. S-adenosylmethionine-dependent methyltransferase Steven G. Clarke and Kelly Banfield
8. S-adenosylhomosysteine hydrolase Sean T. Prigge and Peter K. Chiang
9. Regulation of homocysteine metabolism James D. Finkelstein
10. Microbial modeling of human disease: homocysteine metabolism Rowena G. Matthews and Martha L. Ludwig
11. Folate metabolism Robert J. Cook
12. Cobalamin-dependent remethylation Ruma V. Banerjee and Horatiu Olteanu
13. Betaine-dependent remethylation Tim Garrow
14. The transsulfuration pathway Warren D. Kruger
Section III. Physiology: 15. Cellular transport and tissue distribution Brian Fowler
16. Homocysteine and the kidney John T. Brosnan
17. Homocysteine and the nervous system Anne M. Molloy and Donald G. Weir
Section IV. Clinical Chemistry: 18. Methodologies of testing Karsten Rasmussen and Jan Möller
19. Methionine loading Nicholas Dudman and Jonathan Silberberg
Part II. Clinical Dysfunction and Hyperhomocysteinemia
Section V. Genetic Disorders: 20. Cystathionine-ß-synthase and its deficiency Jan P. Kraus and Viktor Kozich
21. Inborn errors of folate and cobalamin metabolism David S. Rosenblatt
22. Polymorphisms of folate and cobalamin metabolism Rima Rozen
Section VI. Acquired Disorders: 23. Folate deficiency Ralph Carmel
24. Cobalamin deficiency Ralph Carmel
25. Vitamin B6 deficiency Jesse F. Gregory III
26. Homocysteine in renal disease Margret Arnadottir and Björn Hultberg
27. Diseases and drugs associated with hyperhomocysteinemia Henk J. Blom
28. Lifestyle factors associated with hyperhomocysteinemia Stein Emil Vollset, Helga Refsum, Ottar Nygard and Per Ueland
Section VII. Clinical Consequences of Hyperhomocysteinemia: 29. Epidemiology: vascular and thrombotic associations Petra Verhoef and Meir Stampfer
30. Homocysteine and coronary artery disease Killian Robinson
31. Homocysteine and cerebrovascular disease J. David Spence and James F. Toole
32. Peripheral arterial disease Godfried Boers
33. Venous disease Armando D'Angelo and Chiara Beltrametti
34. Homocysteine and hemostasis Katherine A. Hajjar
35. Cellular mechanisms of homocysteine pathogenesis in atherosclerosis Donald W. Jacobsen
36. Homocysteine and cardiovascular physiology Steven R. Lentz
37. Homocysteine and human reproduction T. K. A. B. Eskes
Section VIII. Intervention and Therapy: 38. Modification of hyperhomocysteinemia John M. Scott
39. Design of clinical trials to test the homocysteine hypothesis of vascular disease Robert Clarke
40. What is a desirable homocysteine level? Johan B. Ubbink
Index.

Subject Areas: Psychiatry [MMH], Haematology [MJF]