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Heterocyclic Compounds as Pharmaceutical Ingredients
Divya Bajpai Tripathy (Edited by), Tripathy (Author), Priyanka Chhabra (Edited by), Anjali Gupta (Edited by)
9781394284801, Wiley
Hardback, published 7 July 2026
576 pages
22.9 x 15.2 x 3.4 cm, 0.919 kg
Unlock the therapeutic potential of N-, O-, and S-based heterocycles with this comprehensive guide to the synthesis, characterization, and biological interactions of the compounds currently redefining modern drug design. Heterocyclic compounds have proven their potential as active pharmaceutical ingredients due to the presence of N, O, and S in their chemical makeup, making them ideal hydrogen bond acceptors. Recently, a large number of heterocyclic compounds have been documented as drugs after clearing all phases of preclinical and clinical trials and are commercially available worldwide. This book provides a comprehensive look at the active profile of heterocyclic compounds and their potential applications as antibacterial, antiviral, anti-inflammatory, and anti-cancer agents, as well as applications in pharmaceutical chemistry, pharmacy, cheminformatics, bioinformatics, and related fields. It covers synthesis and characterization, biological interaction mechanisms, proteomics and genotypic activity, and their role in treating diseases including cancer and AIDS. It also addresses challenges such as bioavailability and toxicity, making it a valuable resource for researchers, students, and professionals in drug design using heterocycles.
Preface xvii 1 Heterocyclic Molecules as an Active Pharmaceutical Ingredient: An Introduction 1 2 Biologically Active Nitrogen Heterocyclic Compounds 27 3 Heterocyclic Compounds as Antimicrobial (Antibacterial, Antifungal, Antiviral, and Anthelmintics) Agent 61 4 Heterocyclic Compounds as Anticancer Agents 123 5 Heterocyclic Compounds as Anti-Inflammatory Agents 179 6 Heterocyclic Compounds as Antioxidant Agents 207 7 Heterocyclic Compounds as Anticonvulsants, Antipyretics, Antiallergic Agents, and Antileprosy Agents 249 8 Heterocyclic Compounds as Antihistamine Agents 269 9 Heterocyclic Compound Having Herbicides Activity 307 10 Heterocyclic Compounds as Antihypertensive Agents 349 11 In Silico Studies on Heterocyclics as an Active Pharmaceutical Agent 389 12 Piperazine Derivatives: Potential Antimicrobial Agents 407 13 Synthetic Drug Discovery Strategy of Benzimidazole Derivatives and Their Applications 443 14 Synthesis and Biological Evaluation of Thiophene- and Piperazine-Based Active Compounds 475 15 Heterocyclic Compounds as Antileprotic Agents 509 16 Bromodomains: Biomedical Applications of Active Ingredients 531 References 543
Anushka Sharma, Awaneet Kaur, Pranav Gupta, Debashis Paramanick and Abdulsalam Alhalmi
Diwakar Chauhan, Monika Chauhan, Priya Tyagi and Amrita Kaushik
Gaurank Pal, Devaang Mathur, Lakshit Srivastav, Vishal Mehare, Ajay Gupta, Shruti Khanna Ahuja and Puja Prasad
Aadya Singh, Priyanshi Kamboj, Pragya Swami, Puja Prasad and Shruti Khanna Ahuja
Hemlata Nimesh, Sagar Kumar and Nidhi Srivastava
Niranjan Kaushik, Shristi Singh, Ajita Paliwal and Sachin Chaudhary
Anushka Sharma, Awaneet Kaur, Pranav Gupta, Debashis Paramanick and Abdulsalam Alhalmi
Avinash Jha, Saurabh Sharma, Deepika Paliwal, Aman Thakur and Saurabh Srivasatva
Niranjan Kaushik, Mridul Singh Sengar, Deepika Paliwal and Nadeem Ahmad Siddique
Manjot Singh, Deepika Paliwal, Aman Thakur, Manvi Karayat and Saurabh Srivasatva
Anurag Paul, Debanjali Adhikary, Abdul Kareem Parchur, Gayatri Sharma and Apoorva Mishra
R. Prathap, Rashmi Dubey, Anjali Gupta and Divya Bajpai Tripathy
Prasad Vijay Korake, Diwakar Chauhan and Subhalaxmi Pradhan
Ayyagari Subramanya Sharma, Subhalaxmi Pradhan and Prashant Kumar
Sanjita Das, Anjali Singh, Shalini Gautam and Gyas Khan
Sweta Raj, Anjan Kumar Nayak, Harsh Vardhan and Divya Bajpai Tripathy
Index 547
Subject Areas: Chemistry [PN]
