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Hepatotoxicity
From Genomics to In Vitro and In Vivo Models
Saura C. Sahu (Edited by), SC Sahu (Author)
9780470057162, Wiley
Hardback, published 14 December 2007
704 pages
25 x 17.5 x 4.4 cm, 1.389 kg
"This provides valuable insight into the current and future directions of research in this field and wil be a valuable resource of up-to-date information for toxicologists, risk assessors, and regulators in academia, industry and government." (Doody's, August 2008)
This book addresses all the current, up-to-date developments in this scientific discipline. Liver is the chief metabolizing site in the body, and thus, it is a major target organ for drug and chemical toxicity. Therefore, hepatotoxicity is an important endpoint in the safety evaluation of drugs and chemicals. Contributions from leading investigators in hepatotoxicity research address current developments in this scientific discipline and discuss use of current cutting edge technology such as microarrays in hepatotoxicity thus providing a better understanding of hepatotoxins, their interactions and mechanisms of action. This valuable authoritative source of information is the first book to address this topic for nearly ten years, making it an essential resource for readers from a wide range of disciplines such as toxicology, pharmacology, hepatology, drug toxicity and food science.
Contributors xi Preface xvii Acknowledgements xix Section 1 Models for Hepatotoxicity Testing 1 Current in vitro Models to Study Drug-Induced Liver Injury 3 2 Utilization of an in vitro Hepatotoxicity Test in the Early Stage of Drug Discovery 57 3 Use of Hepatocytes for Characterizing a Candidate Drug’s Metabolism and Drug Interaction Potential 69 4 Human-Based in vitro Experimental Systems for the Evaluation of Human Drug Safety 89 5 Hepatocytes as a Model for Screening Food-Related Hepatotoxins and Studying Mechanisms of their Toxicity 105 6 Some Experimental Models of Liver Damage 119 Section 2 Hepatocyte Cultures 7 Application of Short- and Long-Term Hepatocyte Cultures to Predict Toxicities 141 Section 3 Biomarkers of Hepatotoxicity 8 Biomarkers of Mycotoxin Exposure in Liver Toxicity 177 Section 4 Mechanisms of Hepatotoxicity 9 Mechanisms of Toxic Liver Injury 191 10 A Role of Cytochrome P450 in Quinone-Induced Hepatotoxicity 287 11 A Mechanistic View of Troglitazone Hepatotoxicity 299 12 Role of the Kupffer Cell in Hepatotoxicity and Hepatocarcinogenesis 313 13 Sinusoidal Cells in Liver Injury and Repair 341 14 Cytokines in Liver Diseases 371 15 Bile Acids as Modulators of Apoptosis 391 16 Drug-Induced Intrahepatic Cholestasis by Interaction with the Hepatic Bile Salt Export Pump (BSEP) 421 Section 5 Genomics of Hepatotoxicity 17 Application of Toxicogenomics in Predicting Hepatotoxicity – Potentials and Challenges 449 18 Genomic Profiling of Liver Injury 465 19 Use of DNA Arrays in Understanding Hepatic Test Systems 489 20 Prediction of Hepatotoxicity Based on the Toxicogenomics Database 507 21 Relationship between N-acetyltransferase-2 Gene Polymorphism and Isoniazid-Induced Hepatotoxicity 531 Section 6 Gender Differences in Hepatotoxicity 22 Human and Animal-Based Differences in Hepatic Xenobiotic Metabolism and Toxicity 539 Section 7 Hepatotoxicity and Hepatocarcinogenicity 23 Hepatotoxicity in Oncology Drug Development 565 24 The Potent Rat Hepatocarcinogen Methapyrilene: An Hypothesis Regarding its Hepatotoxicology 577 Section 8 Hepatotoxicity and Botanical Supplements 25 Botanical Supplements and Hepatotoxicity 591 Section 9 Risk Analysis of Hepatotoxins 26 Physiologically Based Pharmokinetic Modeling and Risk Assessment of Hepatotoxicants 609 Index 635
Julio C. Davila, Jinghai J. Xu, Keith A. Hoffmaster, Peter J. O’Brien and Stephen C. Storm
Ikuo Horii, Hiroshi Yamada, Rie Kikkawa, Toshinori Yamamoto, Tamio Fukushima and Kaori Tomizawa
Srikanth C. Nallani, John M. Strong and Shiew Mei Huang
Albert P. li
Saura C. Sahu
Pablo Muriel
Gregor Tuschl, Jens Hrach, Philip G. Hewitt and Stefan O. Mueller
Angela J. Harris
Nora Anderson and Jürgen Borlak
Yasuhiro Ishihara and Norio Shimamoto
Rawiwan Maniratanachote and Tsuyoshi Yokoi
James E. Klaunig, Stacy M. Corthals, Lisa M. Kamendulis and Binu K. Philip
Carol R. Gardner and Debra L. Laskin
Pablo Muriel
Rui E. Castro, Susana Solá, Clifford J. Steer and Cecília M.P. Rodrigues
Christoph Funk, Johannes Noé, Renée Portmann, Ruben Alvarez-Sánchez, Florian Klammers, Christiane Lamy, Axel Paehler and Michael Pantze
Wen Lin, Guoxiang Shen, Tin Oo Khor and Ah-Ng Tony Kong
Kevin Gerrish and David E. Malarkey
Angela J. Harris and Daniel A. Casciano
Tetsuro Urushidani
Yasuo Shimizu, Kunio Dobashi and Masatomo Mori
Peter J. O’Brien, Katie Chan and Raymond J. Poon
Wei Chen, Kenneth Hastings and John K. Leighton
Daniel A. Casciano
Shabana Khan, Ikhlas Khan and Larry Walker
Kannan Krishnan
Subject Areas: Chemistry [PN]
