Hemophilia and Von Willebrand Disease
Factor VIII and Von Willebrand Factor

Serves as a must-have reference on the important role Factor VIII, an essential blood-clotting protein, plays in research and clinical medicine

David Green (Author)

9780128129548, Elsevier Science

Paperback, published 19 June 2018

286 pages
22.9 x 15.1 x 1.9 cm, 0.43 kg

Hemophilia and Von Willebrand Disease: Factor VIII and Von Willebrand Factor serves as a must-have reference on the important role these essential blood-clotting proteins play in research and clinical medicine. Clinicians and researchers face the daily challenge of staying current on the vast amounts of research that is now generated. The reference to Janus in the title refers to the two roles of the Factor VIII/Von Willebrand Factor Complex: initiation of coagulation and propagation of clot formation. The complex prevents bleeding in hemophilia and Von Willebrand disease but also augments arterial and venous thrombosis.

1. Historical Background2. Factor VIII: Anatomy and Physiology3. Genetic Basis of Hemophilia4. Factor VIII Therapy for Bleeding5. Complications of Therapy6. Acquired Disorders of Factor VIII7. Factor VIII and Thrombosis8. Factor VIII: Future Directions

Subject Areas: Haematology [MJF]