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Handbook of the Biology of Aging
Updates on how basic aging processes and medical physiology affect biological systems
Nicolas Musi (Edited by), Peter Hornsby (Edited by)
9780128159620, Elsevier Science
Paperback, published 22 January 2021
468 pages
27.6 x 21.5 x 2.9 cm, 1.29 kg
Handbook of the Biology of Aging, Ninth Edition, provides a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology. The book focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and metabolomics methodologies applied to aging related problems. Sections cover longevity pathways and interventions that modulate aging, innovative tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, and much more.
Part I: Basic mechanisms, underlying physiological changes, model organisms and interventions 1. Longevity as a complex genetic trait 2. DNA damage and repair in aging 3. Mechanisms of cell senescence in aging 4. The nature of aging and the geroscience hypothesis 5. Sirtuins, healthspan, and longevity in mammals 6. Integrative genomics of aging 7. Thermogenesis and aging 8. Yeast as a model organism for aging research 9. Model organisms (invertebrates) 10. NIA Interventions Testing Program: A collaborative approach for investigating interventions to promote healthy aging 11. Aging in nonhuman primates Part II: Organ systems in humans and other animals, human health and longevity 12. Senotherapeutics: Experimental therapy of cellular senescence 13. The role of neurosensory systems in the modulation of aging 14. Aging of the sensory systems: hearing and vision disorders 15. Cardiac aging 16. The aging immune system: Dysregulation, compensatory mechanisms, and prospects for intervention 17. Microbiome changes in aging 18. Lipidomics of aging 19. Trends in morbidity, healthy life expectancy, and the compression of morbidity
Subject Areas: Educational psychology [JNC], Physiological & neuro-psychology, biopsychology [JMM], Psychology of ageing [JMD], Child & developmental psychology [JMC]
