Handbook of Nucleoside Synthesis

Helmut Vorbrüggen (Author), Carmen Ruh-Pohlenz (Author)

9780471093831, Wiley

Paperback / softback, published 2 August 2001

646 pages
23 x 15.6 x 2.8 cm, 0.866 kg

"...an insightful and detailed analysis?provides a valuable resource for the practitioner and a solid foundation for those new to nucleoside synthesis." (Journal of Medicinal Chemistry, Vol. 45, No. 4, 2002)

"...contains much more information than one can assemble from a literature search...allows the reader to compare reaction conditions and the outcome of the reaction...the value of the book is considerable increased by the inclusion of experimental details and protocols based on the experience of the authors...highly recommended for everybody interested.... It is expected that this book will become, just like the Vorbruggen reaction itself, a classic in nucleoside chemistry." (Angewandte Chemie International Edition, Vol. 41, No. 9, 2002)

Handbook of Nucleoside Synthesis includes descriptive information regarding the three principal types of nucleoside forming reactions: the Fusion Reaction, the Metal Salt Procedure, and the Hilbert-Johnson Reaction, as well as other miscellaneous methods.

Foreword.

Preface.

Acknowledgments.

Synthesis of Nucleosides.

Introduction.

Nucleoside Synthesis.

Silyl-Hilbert-Johnson Reaction in the Presence of Friedel-Crafts Catalysts.

Mechanism of Nucleoside Formation in the Presence of Friedel-Crafts Catalysts.

Special Preparations.

Miscellaneous Methods.

Alternative Nucleoside-Forming Reactions.

Experimental Conditions.

Experimental Procedures.

Tabular Survey.

References.

Index.

Subject Areas: Chemistry [PN]