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Genomic and Epigenomic Biomarkers of Toxicology and Disease
Clinical and Therapeutic Actions
Saura C. Sahu (Edited by), SC Sahu (Author)
9781119807674, Wiley
Hardback, published 19 May 2022
512 pages
25.4 x 17.8 x 3.2 cm, 1.191 kg
Genomic and Epigenomic Biomarkers of Toxicology and Disease The latest developments in biomarker research applicable to toxicology and medicine Research on genomic and epigenomic biomarkers is developing rapidly with cutting-edge studies scattered throughout the academic literature, making the status of ongoing scientific activity in this area difficult to ascertain. Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions delivers a comprehensive and authoritative compilation of up-to-date developments in the application of genomic and epigenomic biomarkers to toxicology, disease prevention, cancer detection, therapeutics, gene therapy, and other areas. With contributions from a collection of internationally recognized investigators, this edited volume offers unique insights into current trends and future directions of research in the discussed areas. Combining state-of-the-art information on genomic and epigenomic biomarkers from a range of specialists from around the world, this monograph includes: Perfect for researchers, toxicologists, risk assessors, and regulators, Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions will also earn a place in the libraries of graduate students with an interest in biomarkers, toxicology, agriculture, or the environment.
Dedication ix Preface xi Acknowledgements xiii List of Contributors xv 1 Genomic and Epigenomic Biomarkers for Predictive Toxicity and Disease 1 2 MicroRNAs as Non-invasive Biomarkers of Toxicity and Chemical Hazard: Genomic and Epigenomic Biomarkers of Toxicology and Disease 7 3 EV (Extracellular Vesicle)-associated miRNAs as Biomarkers of Toxicity 37 4 Circulating miRNAs as Biomarkers of Toxic Heavy Metal Exposure 63 5 MicroRNA Biomarkers of Malignant Mesothelioma 89 6 Role of Non-coding RNAs in Innate Immune Responses Perturbed by Environmental Arsenic Exposure 101 7 Transcriptomics: Applications in Toxicology and Medicine 133 8 Network Biology for Biomarker Discovery and Therapy in Cancer 163 9 Epigenetic Biomarkers: Link to Maternal Exposure and Offspring Health Outcomes 185 10 The Role of Dynamic Epigenetic Changes in Modulating Homeostasis after Exposure to Low-dose Environmental Chemicals 213 11 Emerging Non-invasive Molecular Biomarkers for Early Cancer Detection 229 12 Aberrant DNA Methylation of Tumor Suppressor Genes and Oncogenes as Cancer Biomarkers 251 13 SMYD Protein Family as Promising Biomarkers for Cancer Diagnosis and Prognosis 273 14 Toward Precision Medicine: Epigenetic Alterations in Human Melanoma 309 15 Currents Trends and Future Perspectives in Our Epigenetic Signatures: What a Diet Can Trigger 333 16 Genetic and Epigenetic Biomarkers of Organophosphate Compounds, Dialkyl Phosphate Exposure, and Their Relation to Biological Effects 363 17 Genetic, Epigenetic, and Anatomical Factors in Agenesis and Development of Female Reproductive Tract 383 18 Cause or Consequence: Epigenomic DNA Methylation Changes in Arsenic- Mediated in Vitro Transformation of Human Prostate Cells 395 19 Epigenetic Regulation of Sex Determination and Toxicity in Nonmammalian Vertebrates 415 20 Characterization of Genomic and Epigenomic Biomarkers of Nanoparticle Toxicity Using the Zebrafish Model System 449 Index 477
Saura C. Sahu
Gail M. Nelson and Brian N. Chorley
Ryuichi Ono, Yusuke Yoshioka, Yusuke Furukawa, Mie Naruse, Makiko Kuwagata, Takahiro Ochiya, Satoshi Kitajima, and Yoko Hirabayashi
Alexandra N. Nail, Ana P. Ferragut Cardoso, Mayukh Banerjee, and J. Christopher States
Lijin Zhu, Fangfang Zhang, Min Zhang, Hailing Xia, Xiuyuan Yuan, and Yanan Gao
Liz Saavedra Perez and Benjamin L. King
Pius Joseph Copyrighted Material
Asim Bikas Das
Jairus Pulczinski, Moira Mccormick, Yuchen Sun, Musa Watfa, Robert YS Cheng, and Wan-Yee Tang
Chongli Yuan, Jennifer L. Freeman, Junkai Xie, and Han Zhao
Jacob Sobota, Yingxue Zhang, Eid Alshammari,and Zhe Yang
Eid Alshammari, Yingxue Zhang, Jacob Sobota, and Zhe Yang
Yingxue Zhang, Eid Alshammari, Jacob Sobota, and Zhe Yang
Carmen Elena Condrat, Elena Codruta Dobrica, Sanda Maria Cretoiu, and Dragos Cretoiu
Elena-Codruța Dobrică, Mihnea-Alexandru Găman, Matei-Alexandru Cozma, and Sanda Maria Cretoiu
David S. Hernández-Toledano and Libia Vega
Tadaaki Nakajima, Tomomi Sato, and Taisen Iguchi
B. Alex Merrick, Dhiral P. Phadke, Ruchir R. Shah, Deepak Mav, and Erik J. Tokar
Genki Yamagishi, Taisen Iguchi, and Shinichi Miyagawa
Athira Sairanthry Suku, Parayanthala Valappil Mohanan, and Jennifer L. Freeman
Subject Areas: Chemistry [PN]
