Genome Chaos
Rethinking Genetics, Evolution, and Molecular Medicine

Details a new, conceptual framework in genome theory --- based on recent leaps in genomic and cytogenomic research

Henry H. Heng (Author)

9780128136355, Elsevier Science

Paperback, published 29 May 2019

556 pages
22.9 x 15.1 x 3.4 cm, 0.88 kg

Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine.

1. From Mendelian Genetics to 4D-Genomics2. Genes and Genomes Represent Different Biological Entities 3. Genome Chaos and Macro-cellular Evolution: How Evolutionary Cytogenetics Unravels the Mystery of Cancer4. Chromosomal Coding and Fuzzy Inheritance5. Why sex? Genome Re-interpretation Dethrones the Queen6. Breaking the Genome Constraint: The Mechanism of Macro-evolution7. The Genome Theory: A New Framework8. The Rationale and Challenges for Precision Medicine

Subject Areas: DNA & Genome [PSAK1], Genetics [non-medical PSAK]