Genetics and Neurobiology of Down Syndrome

Comprehensive review of the genetics and neurobiology underlying Down Syndrome

Bani Bandana Ganguly (Author)

9780323904568, Elsevier Science

Paperback / softback, published 25 August 2022

498 pages
22.9 x 15.2 x 3.1 cm, 1 kg

Genetics and Neurobiology of Down Syndrome provides a thorough review of the genetic etiology and mechanisms of trisomy 21. The author discusses the history of the syndrome, along with the clinical features and health consequences, including physical features, cognitive, and neurologic symptoms. Genetic counseling on pros and cons of prenatal screening and testing and associated ethical issues are explored. This unique book also covers the societal and demographic aspects as well as the future direction of therapeutic development.

Overview Bani Ganguly Preface Bani Ganguly 1. History and Overview of Down Syndrome: Then and Now Bani Ganguly and Nitin Kadam 2. Congenital features and health aspects in Down syndrome Bani Ganguly and Nitin Kadam 3. Chromosomal cause of Down syndrome Bani Ganguly 4. Possible Causes of Chromosomal Non-Disjunction Bani Ganguly 5. Prevention: Prenatal Screening, Testing and Genetic Counseling, and Socio-cultural Aspects of Down Syndrome Bani Ganguly 6. Gene-dosage imbalance of trisomic HSA21 and Genotype-phenotype association in Down syndrome Bani Ganguly 7. Development of specific phenotypes and genetic consequences in Down syndrome: malformations in craniofacial and cardiac anatomy, and development of leukemia and cognitive and learning deficits Bani Ganguly 8. Mitochondrial dysfunction in Down syndrome Bani Ganguly 9. Mitochondrial abnormalities on patho-biology in Down syndrome Bani Ganguly 10. Neurogenesis and genetic consequences in Down syndrome Bani Ganguly 11. Glutamatergic and GABAergic mechanisms and therapeutic targets in Down Syndrome Bani Ganguly 12. Alzheimer Disease in Down syndrome (DSAD) Bani Ganguly 13. MicroRNAs and epigenetic signatures in Down syndrome Bani Ganguly 14. In vivo and in vitro models for research on Down syndrome Bani Ganguly

Subject Areas: Neurosciences [PSAN], Genetics [non-medical PSAK]