Genetic Variation and Human Disease
Principles and Evolutionary Approaches

This book provides an overview of the concepts and methods needed to understand the genetic basis of biological traits, including disease, in humans.

Kenneth M. Weiss (Author)

9780521336604, Cambridge University Press

Paperback, published 27 January 1995

380 pages, 71 b/w illus. 42 tables
22.9 x 15.2 x 2.1 cm, 0.56 kg

'By far the best introduction to the subject that I have read.' D. Weatherall, Science Publicity

Recent developments in molecular and computational methods have made it possible to identify the genetic basis of any biological trait, and have led to spectacular advances in the study of human disease. This book provides an overview of the concepts and methods needed to understand the genetic basis of biological traits, including disease, in humans. Using examples of qualitative and quantitative phenotypes, Professor Weiss shows how genetic variation may be quantified, and how relationships between genotype and phenotype may be inferred. This book will appeal to many biologists and biological anthropologists interested in the genetic basis of biological traits, as well as to epidemiologists, biomedical scientists, human geneticists and molecular biologists.

Preface
Part I. Genes and Their Expression: 1. What is a gene?
2. The logic of the genome
3. Concepts of frequency and association in populations
4. Genes and phenotypes in populations
Part II. Introduction to Genetic Epidemiology: Inference from Observational Data: 5. Segregation analysis: discrete traits in families
6. Segregation analysis: quantitative traits in families
7. Linkage analysis: finding and mapping genes for qualitative traits
8. Linkage analysis: finding and mapping genes for quantitative traits
Part III. Evolution: The Time Dimension in Populations: 9. Genes over time and space
10. Reconstructing history: the footprints of evolution
11. Evolution generates heterogeneity
Part IV. Modification of the Inherited Genotype: The Time Dimension in Individuals: 12. Phenotype amplification by the environment
13. Infectious disease: the response to biological challenge
14. Variation within the inherited genotype
15. Cancer and ageing: a microcosm of evolution during life
Afterwords: towards a unified general model
Conclusion
Notes
References
Index.

Subject Areas: Human biology [PSX], Medical genetics [MFN], Physical anthropology [JHMP]