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Genetic Toxicology Testing
A Laboratory Manual
Reviewing genetic toxicology testing of chemicals in a Good Laboratory Practice (GLP) environment, this practical guide covers the most commonly used assays—from laboratory ad test design to results analysis—as well as individual test methods, equipment, suggested suppliers, recipes for reagents, and evaluation criteria
Ray Proudlock (Edited by)
9780128007648
Paperback, published 26 May 2016
460 pages
23.4 x 19 x 2.9 cm, 0.93 kg
Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria. An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in your genetic toxicology tests. Genetic Toxicology Testing: A Laboratory Manual is an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own.
1. Introduction
2. Laboratory Design and Safety
3. Formulation
4. Bacterial Mutation Test
5. The Mouse Lymphoma TK Assay
6. In Vitro Micronucleus
7. In Vitro Chromosome Aberration
8. Rodent Micronucleus
9. Rodent Chromosome Aberration
10. Comet Assay
11. PigA Mammalian Erythrocyte Mutation
Subject Areas: Medical toxicology [MMGT], Medical genetics [MFN]
