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Genetic Techniques for Biological Research
A Case Study Approach
Corinne A. Michels (Author)
9780471899198, Wiley
Hardback, published 22 April 2002
254 pages
25.1 x 17.2 x 1.9 cm, 0.567 kg
"...Students new to yeast genetics and those of us keeping abreast of fusing disciplines should add this publication to our reading list..." (The Biochemist, 4 October 2002) "... useful addition to the literature..." (Biologist, Vol.50. No.2, 2003) "...a valuable addition to the reference library of any research laboratory at universities, research institutes and the industry." (Acta Biotechnologica, Vol.23, No.2-3, 2003) "...The aim of every teacher is to inspire students to move down from the stands, step up to the plate, and start hitting on their own. This book is a wonderful tool to help in that quest." (Cell Biology Education, 16 June 2003)
"Genetic Techniques for Biological Research" ist ein Lehrbuch für fortgeschrittene Studenten und Doktoranden der Genetik, Molekularbiologie und Zellbiologie. Es basiert auf Fallstudien zur Hefe Saccharomyces als genetischem Modellorganismus, an dem anschaulich Theorie und Praxis der molekulargenetischen Analyse demonstriert wird. Darüber hinaus bietet es dem Leser umfassende Informationen, damit er diesen Ansatz in seine eigenen Forschungsprojekte einbauen kann. Autorin Corinne Michels - eine Expertin auf dem Gebiet der Hefegenetik und Molekularbiologie - erklärt hier genau, wie man praktische genetische Studien mit Hilfe von durchgearbeiteten Beispielen kritisch bewertet. Auf diese Weise soll der Leser die Fähigkeit zu kritischem Denken entwickeln, um das Material in eigenen Forschungsarbeiten anwenden zu können. Ein idealer Studienbegleiter zu Theorie und Praxis der molekulargenetischen Analyse!
Introduction. SECTION I: SACCHAROMYCES CEREVISIAE AS A GENETIC RESEARCH ORGANISM. Saccharomyces cerevisiae As a Genetic Model Organism Techniques in Cell and Molecular Biology Saccharomyces Cell Structure. SECTION II: TECHNIQUES OF GENETIC ANALYSIS. Mutant Hunts - To Select or to Screen (perhaps even by brute force). Complementation Analysis: How many Genes are Involved? Epistasis Analysis. Gene Isolation and Analysis of Multiple Mutant Alleles. Suppression Analysis. Enhancement and Synthetic Phenotypes Two-hybrid Analysis Advanced Concepts in Molecular Genetic Analysis Genomic Analysis SECTION III: CASE STUDIES FROM THE SACCHAROMYCES GENETIC LITERATURE. Case Study I: Glucose Sensing and signaling Mechanisms in Saccharomyces. Case Study II: Secretion, Exocytosis and Vesicle Trafficking in Saccharomyces. Case Study III: The Cell Division Cycle of Saccharomyces. Case Study IV: Mating-type Pheromone Response Pathway of Saccharomyces. Index.
Subject Areas: Biology, life sciences [PS]
