Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders

Presents the most up-to-date findings in translational models of autism, along with bench-to-bedside translational research

Anantha Shekhar (Volume editor)

9780444641946, Elsevier Science

Hardback, published 16 November 2018

232 pages
23.4 x 19 x 2.1 cm, 0.63 kg

Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders, Volume 241 provides the most recent information on the animal model systems that are available to study different forms of autism spectrum disorders. In addition to genetically engineered animals that uniquely model genetic forms of ASD, this volume also provides detailed chapters on a variety of specific topics, including An overview of genetic models of ASDs, Phenotypic modeling of ASD symptoms, Molecular mechanisms of NF1 model of ASD symptoms, Ube3a gene dosage disorders: molecular and circuit mechanisms of ASD, Circuit dysfunctions in ASD models, ERK signaling in genetic models of ASD, and more.

1. Overview of genetic models of autism spectrum disordersJheel Patel, Jodi Lukkes and Anantha Shekhar2. Neurofibromatosis type 1 as a model system to study molecular mechanisms of autism spectrum disorder symptomsAndrei I. Molosh and Anantha Shekhar3. ERK/MAPK signaling and autism spectrum disordersJoseph Vithayathil, Joanna Pucilowska and Gary E. Landreth4. From bedside to bench and back: Translating ASD modelsDrozd H. P., S.F. Karathanasis S. F., Molosh A, Lukkes J, D. Wade Clapp and A. Shekhar5. Studying child development in genetic models of ASDShruti Garg and Jonathan Green6. Measurement considerations in pediatric research on autism spectrum disordersKarin S. Walsh and Srishti Rau

Subject Areas: Neurosciences [PSAN], Neurology & clinical neurophysiology [MJN], Clinical & internal medicine [MJ], Physiological & neuro-psychology, biopsychology [JMM]