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Fundamentals of Molecular Virology
Christopher D. Richardson (Edited by), Acheson (Author), Nicholas H. Acheson (Edited by)
9781119885863, Wiley
Paperback / softback, published 26 May 2025
672 pages
27.2 x 21.3 x 3.3 cm, 1.769 kg
Comprehensive coverage of major families of viruses, including human pathogens and viruses of organisms from bacteria to plants, with updated information on antiviral drugs, vaccines, antiviral immunity, and gene therapy Fundamentals of Molecular Virology is a textbook designed for university students learning about viruses at the undergraduate or graduate levels. Chapters contributed by prominent virologists cover many of the major virus families. Each chapter is designed to tell a story about the viruses covered, including information on discovery, diseases and pathogenesis, virus structure, steps in replication, and interaction with cellular signaling pathways. This approach portrays the "personality" of each virus, helping students to learn the material and build up their knowledge of virology starting with smaller and simpler viruses and proceeding to more complex viruses. Major importance is given to viruses that infect humans and cause disease, but coverage is broad, including viruses of bacteria, Archaea, algae, invertebrates, and plants. Information boxes highlight applications and research directions of particular significance. Chapters conclude with sections presenting fundamental concepts, review questions, and lists of key terms, which are defined in a glossary at the end of the book. This 3rd edition of Fundamentals of Molecular Virology includes detailed information on the recent COVID-19 pandemic and mRNA vaccine technology, additional sections on pathogenic herpesviruses, and updates on recent outbreaks of Zika virus, Ebola virus and mpox diseases. New chapters describe hepatitis C virus, rhabdoviruses, viruses of invertebrates, oncolytic viruses, and virus-mediated gene therapy. All chapters, including those on innate and adaptive immune responses to virus infections, virus vaccines, and antiviral agents, were revised and updated.
Section I: Introduction to Virology 1. Introduction to Virology 2 2. Virus Structure and Assembly 19 3. Virus Classification: The World of Viruses 32 4. Virus Entry 47 Section II: Viruses of Bacteria and Archaea 5. Single-Stranded RNA Bacteriophages 60 6. Microviruses 74 7. Bacteriophage T7 84 8. Bacteriophage T4 94 9. Bacteriophage Lambda 110 10. Viruses of Archaea 123 Section III: Positive-Strand RNA Animal Viruses 11. Picornaviruses 140 12. Flaviviruses 152 13. Hepaciviruses 164 14. Togaviruses and Rubella Virus 178 15. Coronaviruses 192 Section IV: Negative-Strand and Double-Stranded RNA Animal Viruses 16. Paramyxoviruses and Pneumoviruses 210 17. Rhabdoviruses 226 18. Filoviruses 237 19. Bunyaviruses 251 20. Influenza Viruses 262 21. Reoviruses 278 Section V: Small DNA Animal Viruses 22. Parvoviruses 292 23. Polyomaviruses 302 24. Papillomaviruses 318 Section VI: Large DNA Animal Viruses 25. Adenoviruses 330 26. Herpesviruses 344 27. Poxviruses 366 Section VII: Viruses with a Reverse Transcriptase 28. Retroviruses 382 29. Human Immunodeficiency Virus 394 30. Hepadnaviruses 406 Section VIII: Viroids and Prions 31. Viroids and Hepatitis Delta Virus 420 32. Prions 431 Section IX: Viruses of Plants, Algae, and Invertebrates 33. Cucumber Mosaic Virus 444 34. Viruses of Algae and Mimivirus, a Giant Virus 457 35. Baculoviruses 478 36. Viruses of Invertebrates 489 Section X: Host Defenses Against Virus Infection 37. Innate Immune Responses Against Virus Infection 506 38. Adaptive Immune Responses to Virus Infection 527 Section XI: Medical Applications of Virology 39. Antiviral Vaccines 542 40. Antiviral Chemotherapy 562 41. Oncolytic Viruses 578 42. Virus-Mediated Gene Therapy 586
Nicholas H. Acheson, McGill University
Christopher D. Richardson, Dalhousie University
Stephen C. Harrison, Harvard University
Nicholas H. Acheson, McGill University
Christopher D. Richardson, Dalhousie University
Ari Helenius, Swiss Federal Institute of Technology, Zurich
Jan van Duin, University of Leiden
Karthik Chamakura, Armata Pharmaceuticals, Inc., Los Angeles
Ryland Young, Texas A&M University
Bentley A. Fane, University of Arizona
Aaron P. Roznowski, University of Arizona
William C. Summers, Yale University
Ian J. Molineux, University of Texas, Austin
Deborah M. Hinton, National Institutes of Health, Bethesda
Eric S. Miller, North Carolina State University
Michael Feiss, University of Iowa
David Prangishvili, Institut Pasteur, Paris Mart Krupovic, Institut Pasteur, Paris
Bert L. Semler, University of California, Irvine
Richard Kuhn, Purdue University
Shelton Bradrick, Trudeau Institute, New York
John Lok Man Law, Memorial University of Newfoundland
Michael Houghton, University of Alberta
Anil Kumar, University of Saskatchewan
Milton Schlesinger, Washington University, St. Louis
Sondra Schlesinger, Washington University, St. Louis
Tom C. Hobman, University of Alberta
Marc Desforges, Ste. Justine Hospital, Université de Montréal
Pierre Talbot, Institut Armand-Frappier
Mark Denison, Vanderbilt University
Nicholas H. Acheson, McGill University
Daniel Kolakofsky, University of Geneva
Laurent Roux, University of Geneva
Christopher D. Richardson, Dalhousie University
Valery Grdzelishvili, University of North Carolina, Charlotte
Cassandra A. Catacalos, University of North Carolina, Charlotte
Heinz Feldmann, Rocky Mountain Laboratories, Montana
Hans-Dieter Klenk, University of Marburg
Nicholas H. Acheson, McGill University
Angela Rasmussen, University of Saskatchewan
Richard M. Elliott, University of Glasgow
Lev Levanov, University of Helsinki
Alexander Plyusnin, University of Helsinki
Dalius J. Briedis, McGill University
Alyson Kelvin, University of Calgary
Kristen M. Ogden, Vanderbilt University
Terence S. Dermody, University of Pittsburgh School of Medicine
Peter Beard, École Polytechnique Fédérale de Lausanne
Sarah Wootton, University of Guelph
Nicholas H. Acheson, McGill University
James A. DeCaprio, Dana-Farber Cancer Institute, Harvard University
Greg Matlashewski, McGill University
Lawrence Banks, International Centre for Genetic Engineering and Biotechnology, Trieste
Miranda Thomas, International Centre for Genetic Engineering and Biotechnology, Trieste
Philip Branton, McGill University
Richard C. Marcellus, McGill University
Luca D. Bertzbach, Leibniz Institute of Virology, Hamburg
Thomas Dobner, Leibniz Institute of Virology, Hamburg
Bernard Roizman, University of Chicago
Gabriella Campadelli-Fiume, University of Bologna
Richard Longnecker, Northwestern University
Bruce Banfield, Queens University
Craig McCormick, Dalhousie University
Richard Condit, University of Florida
Matthew D. Gresseth, Medical University of South Carolina
Paula Traktman, Medical University of South Carolina
Alan Cochrane, University of Toronto
Alan Cochrane, University of Toronto
Christopher D. Richardson, Dalhousie University
William Addison, University of Alberta D.
Lorne Tyrrell, University of Alberta
Jean-Pierre Perreault, Université de Sherbrooke
Martin Pelchat, University of Ottawa
Charith Raj Adkar-Purushothama, Université de Sherbrooke
Dalius J. Briedis, McGill University
David Westaway, University of California, San Francisco
Marilyn J. Roossinck, Pennsylvania State College of Agricultural Sciences
Michael J. Allen, University of Exeter
William H. Wilson, Marine Biological Association, Plymouth
John A. Duffy, University of Exeter
Eric Carstens, Queens University
Robert L. Harrison, U.S. Department of Agriculture, Beltsville, Maryland
Peter Krell, University of Guelph
Karen Mossman, McMaster University
John Hiscott, Istituto Pasteur-Fondazione Cenci Bolognetti, Rome
Alessandra Zevini, Istituto Pasteur-Fondazione Cenci Bolognetti, Rome
Malcolm G. Baines, McGill University
Karen Mossman, McMaster University
Naglaa Shoukry, University of Montreal
Brian Ward, McGill University
Hilary E. Hendin, McGill University
Donald M. Coen, Harvard Medical School
Vishnupriyan Kumar, Dalhousie University
Liang-Tzung Lin, Taipei Medical University
Shashi Gujar, Dalhousie University
Richard Peluso, Renovacor, Philadelphia
Christopher D. Richardson, Dalhousie University
Subject Areas: Biology, life sciences [PS]
