Fundamentals of Inflammation

Provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion.

Charles N. Serhan (Edited by), Peter A. Ward (Edited by), Derek W. Gilroy (Edited by), Samir S. Ayoub (Contributions by)

9780521887298, Cambridge University Press

Hardback, published 26 April 2010

488 pages, 99 b/w illus. 44 tables
28.6 x 22 x 2.6 cm, 1.61 kg

'… a comprehensive volume that brings together many important and contemporary aspects of inflammation. This book will serve as an excellent guide to the current understanding of how 'inflammation' contributes in such diverse ways to disease processes, and to the resolution of the same through natural processes or clinical treatment.' The Quarterly Review of Biology

The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.

Part I: 1. Acute inflammation and chronic inflammation Peter Ward
2. Resolution of acute inflammation and wound healing Derek W. Gilroy
3. Links between innate and adaptive immunity Christopher L. Karp
Part II. Individual Cell Types: 4A. Neutrophils I Jose U. Scher, Steven B. Abramson and Michael H. Pillinger
4B. Neutrophils II Marco A. Cassatella
5. Mast cells as sentinels of inflammation Joshua A. Boyce
6. Basophils Jonathan Arm and David Sloane
7. Eosinophils Sophie Fillon, Steven J. Ackerman and Glenn T. Furuta
8. Macrophages Sarah Fox and Adriano G. Rossi
9. Lymphocytes Tracy Hussell
10. Fibroblasts and stromal cells Andrew Filer and Christopher D. Buckley
11. Cell-cell interactions: PMN endothelial cells János G. Filep and Sean Colgan
Part III. Chemical Mediators: 12. Lipid mediators in acute inflammation and resolution: eicosanoids, PAF, resolvins and protectins Charles Serhan and Jesper Z. Haeggström
13. Cytokines and chemokines / IL-1 family in inflammation Nick Lukacs
14. Adenosine receptors: therapeutic aspects for inflammatory and immune diseases György Haskó and Bruce Cronstein
15. Leukocyte generation of reactive oxygen species William Nauseef
16. Cell adhesion molecules Lucy V. Norling, Giovanni Leoni, Dianne Cooper and Mauro Perretti
Part IV. Immunopharmacology: 17. Mediators and mechanisms of inflammatory pain Tony L. Yaksh
18. Non-steroidal anti-inflammatory drugs Roderick Flower and Samir S. Ayoub
19. Cytokines and chemokines in inflammation cancer Thorsten Hagemann and Toby Lawrence
Part V. Inflammatory Diseases/Histology: 20. Lung Bruce D. Levy
21. Neural inflammation, Alzheimer's disease and stroke Andrew P. Lieberman and Constance D'Amato
22. Rheumatoid arthritis/SLE Karim Raza and Caroline Gordon
23. Gastrointestinal inflammation and ulceration: mediators of induction and resolution Linda Vong, Paul L. Beck and John Wallace
24. Inflammatory skin diseases Gayathri K. Perera and Frank Nestle
25. Kidney glomerulonephritis and renal ischemia Jeremy Duffield and Joel Henderson
26. Inflammation in cardiovascular diseases Kenneth K. Wu
Part VI. Animal Models of Inflammation: 27. Models of acute inflammation – air-pouch, peritonitis and ischemia-reperfusion André L. F. Sampaio, Neil Dufton and Mauro Perretti
28A. Experimental models of glomerulonephritis Aidan Ryan, Denise M. Sadlier and Catherine Godson
28B. Ischemia reperfusion injury and glomerulonephritis Jeremy Duffield
29. Asthma Bruce D. Levy
30. Arthritis Mike Seed
31. Ocular inflammation models Karsten Gronert
32. Atherosclerosis in experimental animal models Aksam Merched and Lawrence Chan
33. Oral inflammation and periodontitis Alpdogan Kantarci, Hatice Hasturk and Thomas E. Van Dyke
34. Pathogens and inflammation Fabiana S. Machado and Julio Aliberti
35. Diabetes Michael J. Clare-Salzler.

Subject Areas: Medical microbiology & virology [MMFM], Infectious & contagious diseases [MJCJ], Clinical & internal medicine [MJ]