From Genome to Therapy
Integrating New Technologies with Drug Development

Gregory R. Bock (Edited by), Novartis (Author), Dalia Cohen (Edited by), Jamie A. Goode (Edited by)

9780471627449, Wiley

Hardback, published 27 September 2000

176 pages
23.8 x 16 x 1.8 cm, 0.369 kg

"It does successfully convey to the reader areas of controversy" (Microbiology Today, November 2001)
"there are a number of nuggets in the book that make it worth a browse." (Pharmaceutical Physician, December 2001)
"I found this book fun to read." (Biochemistry & Molecular Biology Education, No.29 2001)
"Contributors...present 17 papers and the discussions they generated at the symposium." (SciTech Book News, Vol. 25, No. 4, December 2001)

Der aktuelle Stand der Sequenzierungsverfahren wird hier von weltweit führenden Experten diskutiert. Daneben wird ein Ausblick auf neue Entwicklungen geboten, wobei der Schwerpunkt auf der Anwendung genetischer Informationen in der Wirkstofforschung liegt. Rechtliche und ethische Aspekte der Verwendung dieser Informationen werden ebenfalls angesprochen. (03/00)

Introduction (J. Venter).

Electrophoresis-Based Fluorescent Dideoxy-Terminator Sequencing (J. Efcavitch).

Genomic Impact on Pharmaceutical Development (J. Venter).

From Transcription Regulation to Cell Cycle Checkpoint (R. Cai, et al.).

Mass Spectrometry Resurrects Protein-Approaches in Functional Genomics (M. Mann).

A Clinical Molecular Scanner to Study Human Proteome Complexity (D. Hochstrasser, et al.).

From Proteomics to Functional Analysis (J. van Oostrum, et al.).

Microbial Genome Sequencing: New Insights into Physiology and Evolution (C. Fraser).

Pharmacogenetics and Pharmacogenomics in the Discovery and Development of Medicines (A. Roses).

Mutagenesis and Genomics in the Mouse: Towards Systematic Studies of Mammalian Gene Function (S. Brown).

Biological Annotation of the Drosophila Genome Sequence (G. Rubin).

Applications of High-Density Oligonucleotide Arrays (R. Lipshutz).

Plasmodium Falciparum: From Genomic Sequence to Vaccines and Drugs (S. Hoffman & D. Carucci).

Functional Analysis of the Yeast Genome by Precise Deletion and Parallel Phenotypic Characterization (E. Winzeler, et al.).

Patenting Genes and Gene Therapy: Legal and Ethical Aspects (J. Straus).

Ethical Issues: From Genome to Therapy (D. Magnus).

The Impact of Genomics on Drug Discovery (P. Goodfellow).

From Genome to Therapy: Industry Perspective (P. Herrling).

Final General Discussion.

Indexes.

Subject Areas: Biology, life sciences [PS]