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Forensic Practitioner's Guide to the Interpretation of Complex DNA Profiles
Filling a gap in the current literature, this clear, simplified referene to DNA mixture interpretation includes examples for the forensice DNA community
Peter Gill (Author), Øyvind Bleka (Author), Oskar Hansson (Author), Corina Benschop (Author), Hinda Haned (Author)
9780128205624
Paperback, published 11 June 2020
530 pages, 150 illustrations (50 in full color)
23.4 x 19 x 3.3 cm, 1.09 kg
Over the past twenty years, there’s been a gradual shift in the way forensic scientists approach the evaluation of DNA profiling evidence that is taken to court. Many laboratories are now adopting ‘probabilistic genotyping’ to interpret complex DNA mixtures. However, current practice is very diverse, where a whole range of technologies are used to interpret DNA profiles and the software approaches advocated are commonly used throughout the world. Forensic Practitioner’s Guide to the Interpretation of Complex DNA Profiles places the main concepts of DNA profiling into context and fills a niche that is unoccupied in current literature. The book begins with an introduction to basic forensic genetics, covering a brief historical description of the development and harmonization of STR markers and national DNA databases. The laws of statistics are described, along with the likelihood ratio based on Hardy-Weinberg equilibrium and alternative models considering sub-structuring and relatedness. The historical development of low template mixture analysis, theory and practice, is also described, so the reader has a full understanding of rationale and progression. Evaluation of evidence and statement writing is described in detail, along with common pitfalls and their avoidance. The authors have been at the forefront of the revolution, having made substantial contributions to theory and practice over the past two decades. All methods described are open-source and freely available, supported by sets of test-data and links to web-sites with further information. This book is written primarily for the biologist with little or no statistical training. However, sufficient information will also be provided for the experienced statistician. Consequently, the book appeals to a diverse audience
1. Forensic genetics: the basics2. Empirical characterization of DNA profiles3. Allele drop-out and the stochastic threshold4. Low-template DNA5. LRmix model theory6. A qualitative (semi-continuous)model: LRmix Studio7. The quantitative (continuous)model theory8. EuroForMix9. Validation10. Development and implementation of DNAxs11. Investigative forensic genetics: SmartRank, CaseSolver and DNAmatch212. Interpretation, reporting, and communication13. Interpretation of complex DNA profiles generated by massively parallel sequencing A. Formal descriptions of the genotype probabilitiesB. Formal description of the probabilisticmodels
Subject Areas: Forensic science [JKVF1]
