Fed-Batch Cultures
Principles and Applications of Semi-Batch Bioreactors

This first book dealing exclusively with every aspect of fed-batch operations, used in most industrially important fermentation and bioreactor operations.

Henry C. Lim (Author), Hwa Sung Shin (Author)

9780521513364, Cambridge University Press

Hardback, published 22 April 2013

471 pages, 121 b/w illus. 41 tables
26 x 18.2 x 2.7 cm, 0.99 kg

Many, if not most, industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. In spite of this, there is no single book that deals with fed-batch operations. This is the first book that presents all the necessary background material regarding the 'what, why and how' of optimal and sub-optimal fed-batch operations. Numerous examples are provided to illustrate the application of optimal fed-batch cultures. This unique book, by world experts with decades of research and industrial experience, is a must for researchers and industrial practitioners of fed-batch processes (modeling, control and optimization) in biotechnology, fermentation, food, pharmaceuticals and waste treatment industries.

1. Introduction to fed-batch bioreactors
2. Idealised reactors and fed-batch reactors
3. Maximisation of reaction rates and fed-batch operation
4. Phenomena that favour fed-batch operations
5. Classification and characteristics of fed-batch cultures
6. Models based on mass balance equations
7. Non-equation-based models
8. Experimental determination of specific rates
9. Optimization via Pontryagin's maximum principle
10. Computational techniques
11. Optimization of single and multiple isothermal reactions
12. Optimization of fed-batch cultures for cell mass production
13. Optimization of fed-batch cultures for metabolites
14. Simple, intuitive adaptive optimization
15. Measurements, estimation and control
16. Feasibility assessment and implementable feed rates.

Subject Areas: Mechanical engineering & materials [TG], Pharmaceutical technology [TDCW], Chemical engineering [TDCB], Industrial chemistry & manufacturing technologies [TD], Microbiology [non-medical PSG], Biomedical engineering [MQW]