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Extremely Preterm Birth and its Consequences
The ELGAN Study

Olaf Dammann (Edited by), O Dammann (Author), Alan Leviton (Edited by), Mike O'Shea (Edited by), Nigel Paneth (Edited by)

9781911488965, Wiley

Hardback, published 31 December 2020

356 pages
23.9 x 17.3 x 1.5 cm, 0.658 kg

This book reviews important findings from the Extremely Low Gestational Age Newborn Study (ELGAN), the largest cohort study ever completed involving individuals born extremely prematurely. With a focus on pre-, peri-, and post-natal inflammation, this study identified potentially modifiable risk factors and pathways antecedent to a broad range of neurodevelopmental impairments, as well as asthma and obesity, during middle childhood. These findings will be of interest to both practicing neonatologists and developmental paediatricians, as well as researchers interested in the prevention of adverse child health outcomes and promotion of positive health among individuals born extremely preterm.

  • The only book to summarise findings from the Extremely Low Gestational Age Newborn Study, the largest and most comprehensive cohort study ever conducted of this high-risk group.
  • A comprehensive ‘one-stop-shopping’ resource.
  • A broad range of neurodevelopmental outcomes are included, as well as the relationship of these outcomes to pre-, peri-, and post-natal risk factors. A focus of the study was perinatal inflammation, and the methods used to evaluate inflammation are the most comprehensive ever undertaken in an epidemiologic study of individuals born extremely preterm.
  • The results of the ELGAN study will help Make a difference in the care and outcome of children born very early and make an important contribution to preventing learning and behavioural problems in children.

 

Introduction

Placenta and Perinatal Risk Factors

Placental Microorganisms in ELGAN with Correlation to Pregnancy Outcomes, Intrauterine Inflammation, and Postnatal and Later-life Outcomes

Correlations of Placental Histology in ELGANs with Delivery Indications, Placental Microbiology, and Childhood Morbidity

Signal Initiators of Early Preterm Birth

Maternal Adiposity

Neonatal Exposures and Outcomes

Illness-Severity and Outcomes among Children Born Extremely Preterm

Bacteremia

Retinopathy of Prematurity

Bronchopulmonary Dysplasia

Structural Brain Disorders

Ultrasound

Multispectral Quantitative MRI: Techniques and Preliminary Results

Functional Brain Disorders

Cerebral Palsy among Children Born Extremely Preterm

Cognitive and Behavioral Functioning

Autism, Social Impairment, and Social Communication Deficits in Children Born Prior to the 28th Week of Gestation

Psychiatric and Behavioral Outcomes at Age 2 and10 Years in Individuals Born Extremely Preterm

Concluding Chapter

Glossary

Subject Areas: Clinical & internal medicine [MJ]
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