Epilepsy
Models, Mechanisms and Concepts

This book considers a number of major concepts and models in epilepsy research, to advance understanding of the basic mechanisms involved.

Philip A. Schwartzkroin (Edited by)

9780521033503, Cambridge University Press

Paperback / softback, published 1 February 2007

560 pages, 75 b/w illus. 11 tables
22.8 x 15.2 x 3.2 cm, 0.829 kg

"This book is an excellent reference for recent work in epilepsy research, in both thought-provoking and technical ways. It is highly recommended for scientists and clinicians interested in epilepsy." Cynthia L. Harden, Quarterly Review of Biology

Advances in epilepsy research are occurring at a rapid rate, resulting in a bewildering wealth of data. The implications of this knowledge for future research and clinical practice can be confusing. This volume concentrates on the concepts and models of epilepsy which have been developed as a result of this research. Written by prominent researchers in the field, this book presents a number of major concepts and hypotheses through which epilepsy research has been advanced. Chapters focus on the pathways and mechanisms through which seizure activity is initiated and spread, in both normal and abnormal brain tissues, and discuss the special properties of epileptogenesis in the immature brain. In a field in which rapid advances lead to constant update of empirical data, this book takes a conceptual approach to the subject and provides a solid framework within which to understand the emerging issues. It will be relevant to basic neuroscientists, neurologists and neurosurgeons.

List of contributors
General introduction Philip A. Schwartzkroin
Part I. Chronic Models in Intact Animals - Concepts and Questions: Introduction
1. The kindling model of epilepsy James O. McNamara, Douglas W. Bonhaus and Cheolsu Shin
2. Focal trigger zones and pathways of propagation in seizure generation Karen Gale
3. Genetic models of the epilepsies Phillip C. Jobe, Pravin K. Mishra, Nandor Ludvig and John W. Dailey
4. Noradrenergic modulation of excitability: transplantation approaches to epilepsy research Olle Lindvall
5. Sensitivity of the immature central nervous system to epileptogenic stimuli Solomon L. Moshé, Patric K. Stanton and Ellen F. Sperber
Part II. Features of the Epileptogenic Brain: Introduction
6. Neurophysiological studies of alterations in seizure susceptibility during brain development John. W. Swann, Karen L. Smith, Robert J. Brady and Martha G. Pierson
7. Electrophysiology and pharmacology of human neocortex and hippocampus in vitro Massimo Avoli
8. Cell death, plasticity and epilepsy: insights provided by experimental models of hippocampal sclerosis JoAnn E. Franck
9. Sprouting as an underlying cause of hyperexcitability in experimental models and in the human epileptic temporal lobe Thomas P. Sutula
10. Rapidly recurring seizures and status epilepticus: ictal density as a factor in epileptogenesis Eric W. Lothman, Janet L. Stringer and Edward H. Bertram
Part III. 'Normal' Brain Mechanisms That Support Epileptiform Activities: Introduction
11. Brain slice models for the study of seizures and interictal spikes Wilkie A. Wilson and Andrew Bragdon
12. Generation of epileptiform discharge by local circuits of neocortex Barry W. Connors and Yael Amitai
13. Study of GABAergic inhibition and GABAA receptors in experimental epilepsy Robert K. S. Wong and Richard Miles
14. High potassium-induced synchronous bursts and electrographic seizures Christopher J. McBain, Stephen F. Traynelis and Raymond Dingledine
15. Anti-epileptic effects of organic calcium channel blockers in animal experiments Erwin-Josef Speckmann and Jörg Walden
Recent advances
Index.

Subject Areas: Neurology & clinical neurophysiology [MJN]