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Epilepsy
A Queen Square Textbook

John S. Duncan (Edited by), Ley Sander (Edited by)

9781394340033, Wiley

Hardback, published 23 April 2026

304 pages
25.6 x 18.3 x 1.8 cm, 0.816 kg

Comprehensive, cutting-edge guide to adult epilepsy from the renowned Queen Square specialists

Epilepsy: A Queen Square Textbook delivers an authoritative and up-to-date overview of the causes, consequences, diagnosis, and treatment of epilepsy in adults. Written by the distinguished Queen Square Epilepsy group, this complete resource synthesises the relevant evidence and applies the latest knowledge to clinical practice, with points of practical importance highlighted throughout.

This essential reference covers:

  • Fundamental aspects: The neurosciences of epilepsy and epileptogenesis, neurophysiology, medical imaging, epidemiology, genetics and the spectrum of epileptic seizures and epilepsies
  • Clinical management: Diagnosis, medical and surgical treatment, neuropsychology, non-pharmacological therapies, status epilepticus, reproduction, epilepsy in older people, sleep, and neurodegeneration
  • Current challenges: Psychiatric and somatic comorbidities, sudden unexpected death in epilepsy (SUDEP), functional dissociative seizures, driving and the law
  • Contemporary issues and emerging technologies: Climate change impacts, the role of artificial intelligence in diagnosis and treatment, and future perspectives in epilepsy management

Epilepsy: A Queen Square Textbook is an indispensable resource for healthcare professionals involved in epilepsy care and research, including neurologists, nurses, neuroscientists, and psychologists—from trainees through to established specialists.

About the Editors vii

List of Contributors ix

Forewords xi

Preface xiv

Acknowledgements xvi

1 What Is Epilepsy? 1

2 Epidemiology and Natural History 6

3 The Spectrum of Seizures and Epilepsies 14

4 Risk Factors for Epilepsy 31

5 Genetics of Epilepsy 43

6 Neuroscience of Epilepsy 50

7 Neurophysiology 60

8 Neuroimaging 77

9 The Role of Neuropsychology in the Management of People with Epilepsy 95

10 First Seizure Clinic, Differential Diagnosis 104

11 Medical Treatment 112

12 Dietary, Psychological and Complementary Therapies 147

13 Epilepsy in the Acute Medical Unit 151

14 Status Epilepticus 159

15 Epilepsy Surgery 167

16 Epilepsy and Reproduction 183

17 Epilepsy in Later Life 193

18 Sleep and Epilepsy 199

19 Epilepsy, Driving, and the Law 206

20 Climate Change and Epilepsy 215

21 Premature Mortality and Sudden Unexpected Death in Epilepsy 219

22 Epilepsy and Neurodegeneration 225

23 Neuropsychiatric Aspects of Epilepsy 235

24 Functional Dissociative Seizures 241

25 Big Data and Artificial Intelligence 252

26 Future Perspectives for Epilepsy 266

Index 274

Subject Areas: Clinical & internal medicine [MJ]
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