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Epigenetics of Chronic Pain
Synthesizes our current understanding of the epigenetic regulation of chronic pain in an accessible and clinically relevant format
Guang Bai (Volume editor), Ke Ren (Volume editor)
9780128140703
Hardback, published 1 November 2018
248 pages
23.4 x 19 x 2.1 cm, 0.68 kg
Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies. The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs.
1. Epigenetic tools in chronic pain studies
2. Epigenetic regulation of peripheral macrophages in neuropathic pain
3. Emphasizing histone-related chromatin remodeling in the central nervous system of animal models of chronic pain
4. Role of histone modifications in chronic pain development
5. Role of DNA Methylation in Chronic Pain
6. Pain-induced chromatin modifications
7. DNA Methylation/Demethylation Homeostasis and Various Pain Conditions
8. Epigenetic Modulation of Visceral Pain
9. Non-coding RNAs are new players in chronic pain
10. Epigenetics of Chronic Visceral Nociception
11. An overview of epigenetic correlates of human chronic pain conditions
Subject Areas: DNA & Genome [PSAK1], Genetics [non-medical PSAK]
