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Epigenetics and Reproductive Health
Discusses epigenetics in reproductive health, with an emphasis on epigenetic causes of disease states, biomarker identification, and enabling drug discovery
Trygve Tollefsbol (Series edited by), Nafisa H Balasinor (Volume editor), Priyanka Parte (Volume editor), Dipty Singh (Volume editor)
9780128197530, Elsevier Science
Paperback, published 18 September 2020
444 pages, 70 illustrations (30 in full color)
23.4 x 19 x 2.8 cm, 0.86 kg
"I believe this to be the first of many textbooks on this topic. It is a much-needed summary of important advancements in the field of epigenetics and reproductive health. It is a very detailed review intended for expects in the field and those devoted to continued research in this area." --Doody
Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted reproductive technologies. Emphasis is placed on identifying biomarkers for early detection of aberrant epigenetic mechanisms. Later chapters examine the possibility of correcting these epigenetic dysfunctions, as well as current challenges and next steps in research, enabling new translational discoveries and efforts towards developing therapeutics.
SECTION I Spermatogenesis, oogenesis and fertility 1. Epigenome reprogramming in the male and female germ line 2. Genomic imprinting 3. Chromatin remodeling of the male genome during spermiogenesis and embryo development 4. Epigenetic regulation in stem cells 5. Aberrant epigenetics and reproductive disorders SECTION II Pregnancy/developmental/placental epigenetics 6. Epigenetic reprogramming in the embryo 7. Epigenetic regulation during placentation 8. Epigenetic modulation during pregnancy and pregnancy related disorders 9. Epigenetic involvement in fetal and neonatal origins of late-onset disease SECTION III Epigenetic – lifestyle, aging and environmental influence 10. Impact of environmental chemicals and endocrine disruptors on mammalian germ cell epigenome 11. Influence of nutrition on reproductive health through epigenetic mechanisms 12. Influence of stress and lifestyle on epigenetic modifications 13. Aging of male and female gametes SECTION IV Reproductive cancer and epigenetics 14. Testicular and prostate cancers 15. Emerging patterns and implications of breast cancer epigenetics: An update of the current knowledge 16. Ovarian and endometrial cancers 17. Epigenetic aberrations in cervical cancer SECTION V Epigenetics in diagnosis, prognosis and therapy 18. Natural molecules as epigenetic modifiers in reproduction
Subject Areas: DNA & Genome [PSAK1], Genetics [non-medical PSAK]
