Epigenetic Technological Applications

Outlining technologies that are critical for epigenetic research and application

Yujun George Zheng (Edited by)

9780128010808, Elsevier Science

Hardback, published 28 July 2015

516 pages, 50
23.4 x 19 x 3 cm, 1.27 kg

Epigenetic Technological Applications is a compilation of state-of-the-art technologies involved in epigenetic research. Epigenetics is an exciting new field of biology research, and many technologies are invented and developed specifically for epigenetics study. With chapters covering the latest developments in crystallography, computational modeling, the uses of histones, and more, Epigenetic Technological Applications addresses the question of how these new ideas, procedures, and innovations can be applied to current epigenetics research, and how they can keep pushing discovery forward and beyond the epigenetic realm.

Preface
1. Introduction of the Epigenetic Technologies
2. Technologies for the Measurement and Mapping of Genomic 5-methylcytosine and 5-hydroxymethylcytosine
3. Technologies to Map DNA 5hC and 5fC and 5caC
4. Application of Mass Spectrometry in Translational Epigenetics
5. Techniques Analyzing Chromatin Modifications at Specific Single Loci
6.  Comprehensive Analysis of Mammalian Linker-histone Variants and Their Mutants
7. Crystallography-based Mechanistic Insights into Epigenetic Regulation
8. Chemical and Genetic Approaches to Study Histone Modifications
9. Peptide Microarrays for Profiling of Epigenetic Targets
10. Current Methods for Methylome Profiling
11. Bioinformatics and Biostatistics for Mining Epigenetic Disease Markers and Targets
12. Computational Modeling to Elucidate Molecular Mechanisms of Epigenetic Memory
13. DNA Methyltransferase Inhibitors for Cancer Therapy
14. Histone Acetyltransferases: Enzymes, Assays, and Inhibitors
15. In Vitro Histone Deacetylase Activity Screening: Making a Case for Better Assays
16. Enzymatic Assays of Histone Methyltransferase Enzymes
17. Histone Methyltransferase Inhibitors for Cancer Therapy
18. Discovery of Histone Demethylase Inhibitors
19. Fluorescent Technologies in Studying Dynamics of Histone Modification
20. Animal Model Study of Epigenetic Inhibitors

Subject Areas: Molecular biology [PSD], Genetics [non-medical PSAK], Crystallography [PNT], Medical genetics [MFN]