Epigenetic Regulation in the Nervous System
Basic Mechanisms and Clinical Impact

This book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. A must-read for neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as well as clinicians dealing with disorders such as addiction, depression, and schizophrenia

J. David Sweatt (Edited by), Michael J. Meaney (Edited by), Eric J. Nestler (Edited by), Schahram Akbarian (Edited by)

9780123914941

Hardback, published 27 February 2013

374 pages
23.4 x 19 x 2.6 cm, 0.99 kg

"The book is primarily intended for advanced undergraduates, graduate students, active researchers and physician-scientists newly interested in the emerging field….Sweatt is also responsible for the book’s extensive illustrations, which are copies of his paintings depicting the role of epigenetic processes in the brain, and relate to work under way in his lab." --UAB News online, February 25, 2013

Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system.Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions.Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia.

1. An Overview of the Molecular Basis of Epigenetics
J. David Sweatt, Michael J. Meaney, Eric J. Nestler, and Schahram Akbarian
2. Histone modifications in the nervous system and neuropsychiatric disorders
Morgan Bridi and Edwin "Ted" Abel
3. Active DNA Demethylation and 5-Hydroxymethylcytosine
Junjie U. Guo, Guo-li Ming and Hongjun Song
4. Maternal Behavior
Tie Yuan Zhang, Christian Caldji, Josie C. Diorio, Sabine Dhir, Gustavo Turecki, and Michael J. Meaney
5. Epigenetic Mechanisms in Learning and Memory
Jeremy J. Day and J. David Sweatt
6. Drug Addiction and Reward
Alfred J. Robison, Jian Feng, and Eric J. Nestler
7. The Mind and its Nucleosomes – Chromatin (dys)regulation in Major Psychiatric Disease
Rahul Bharadwaj, Cyril J. Peter, and Schahram Akbarian
8. HDAC inhibitors as novel therapeutics in Aging, and Alzheimer's disease
Alexi Nott, Daniel M. Fass, Stephen J. Haggarty, and Li-Huei Tsai
9. Cell Differentiation in the CNS, Neuronal Fate Determination, and Development
Yi Eve Sun
10. Imprinting in the CNS and Neurodevelopmental Disorders
Weston T. Powell and Janine LaSalle
11. Neuronal Genomic and Epigenetic Diversity
Michael J. McConnell and Fred H. Gage
12. Adult Neurogenesis
Jenny Hsieh, Hongjun Song
13. Transgenerational Inheritance in Mammals
Isabelle M. Mansuy, Rahia Mashoodh and Francis A. Champagne
14. Open Questions and Future Approaches in Neuroepigenetics
J. David Sweatt, Michael J. Meaney, Eric J. Nestler, and Schahram Akbarian

Subject Areas: Psychiatry [MMH], Neurology & clinical neurophysiology [MJN], Physiological & neuro-psychology, biopsychology [JMM]