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Environmental Epigenetics in Toxicology and Public Health
Offers an in-depth discussion of the environmental determinants of epigenetic mechanisms in human development and disease
Rebecca Fry (Edited by), Trygve O Tollefsbol (Series edited by)
9780128199688, Elsevier Science
Paperback, published 23 October 2020
364 pages, 60 illustrations (30 in full color)
23.4 x 19 x 2.3 cm, 0.79 kg
"This is an important entry in the Translational Epigenetic series at a time that such methods are moving from a status of novel to practice and even translational. This beautifully illustrated volume in the series will likely become useful, if not essential, for two groups -- graduate students encountering the material for the first time and seasoned professionals, often researchers, who have read about these techniques and now wish to employ them. Given the emergence of this field, I don't believe many years will pass before a second edition is necessary. This is perhaps the most essential public health book I have reviewed in some time." --© Doody’s Review Service, 2021, John T. Pierce, MBBS(MD), reviewer, expert opinion
Environmental Epigenetics in Toxicology and Public Health provides in-depth discussions of the suite of complex environmental factors shown to impact epigenetic components within the cell, as well as evidence that these epigenetic modifications are tied to early and later life health effects. This book offers a translational research perspective, highlighting both in vivo and human population-based evidence for ties between the environment, the epigenome, and health outcomes, with an emphasis on evidence for transgenerational effects of exposures, as well as developmental windows of susceptibility to environmentally-linked epigenetic effects. This volume in the Translational Epigenetics series aides in the development of new therapeutic options meant to reverse inappropriate epigenetic alterations, helping researchers in their efforts prevent and treat a variety of chronic diseases tied to environmental exposures.
Section I. Epigenetic Mechanisms/Machinery 1. DNA methylation/chromatic regulation/non-coding RNAs 2. Tools for the assessment of epigenetic regulation Section II. Transdisciplinary approaches for the study of environmental epigenetics 3. Model organisms and their application in environmental epigenetics 4. Epidemiological concepts in environmental epigenetics Section III. Epigenetic programming of disease in relation to the environment 5. Pregnancy and Birth outcomes 6. Neurodevelopment outcomes 7. Cancer 8. Respiratory dysfunction 9. Immune dysfunction 10. Cardio/Metabolic disease 11. Aging Section IV. Transgenerational epigenetic effects of the environment 12. Transgenerational effects of environmental contaminants Section V. Epigenome-targeted therapies in environmental health science 13. Nutrition 14. Manipulation of Epigenetic machinery Section VI. Conclusions and Future Perspectives 15. Conclusions and Future Perspectives: The environment and the epigenome
Subject Areas: DNA & Genome [PSAK1], Genetics [non-medical PSAK]
