Emerging Concepts in Ribosome Structure, Biogenesis, and Function

Comprehensive resource on emerging research on ribosomes, including their biogenesis, structure and function

Vijay Kumar (Edited by)

9780128163641, Elsevier Science

Paperback, published 30 September 2021

296 pages
22.9 x 15.2 x 1.9 cm, 0.48 kg

Ribosome biogenesis is the process of making ribosomes which are responsible for mRNA translation into proteins. It is a tightly regulated process closely linked to nearly all biochemical and cellular processes, including cell division, growth, and development. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides a synthesized overview of all the parts engaged in this process. The book begins by providing an introduction to the ribosome factory, its origin, and its evolution of translation. It then goes on to describe ribosome structure including subunits, RNA, and protein components. Ribosome biogenesis and its emergence as a frontier research area for translational potential in cancer and other diseases are also discussed. In addition, the book explores current developments in ribosome research like the emergence of ribosomopathies, how deregulation of ribosome biogenesis can impact disease mechanisms and aging, and the discovery of specialized ribosomes that have specific functions that may translate differentially with consequences on normal and pathological processes. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides fundamental coverage and emerging research on ribosomes, biogenesis, and their structure and function and is a resourceful introduction for new researchers and those engaged in interdisciplinary ribosomal research.

1. Introduction to ribosome factory, origin and evolution of translation
2. Ribosome structure
3. rDNA gene structure, transcription and their co-regulation
4. Ribosomal proteins - their balanced production
5. Ribosome diversity
6. Ribosome cycle - Assembly, degradation, and recycling
7. Ribosomal biogenesis in eukaryotes
8. Protein biogenesis in prokaryotes
9. Translation - Process and control
10. Inhibitores of ribosome biogenesis in prokaryotes and eukaryotes
11. Ribosomopathies - A tree of pathologies with many roots and branches!
12. Ribosomal profiling - Diversity and applications

Subject Areas: Cellular biology [cytology PSF], Molecular biology [PSD], Genetics [non-medical PSAK]