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Emerging Cancer Therapy
Microbial Approaches and Biotechnological Tools
Arsenio Fialho (Edited by), A Fialho (Author), Ananda Chakrabarty (Edited by)
9780470444672, Wiley
Hardback, published 16 July 2010
448 pages
24.1 x 16 x 3 cm, 0.821 kg
Explores current and emerging applications of microbes as cancer-fighting agents WILEY SERIES IN BIOTECHNOLOGY AND BIOENGINEERING Anurag S. Rathore, Series Editor Today, treatment options for cancer patients typically include surgery, radiation therapy, immunotherapy, and chemotherapy. While these therapies have saved lives and reduced pain and suffering, cancer still takes millions of lives every year around the world. In recent years, researchers have been working on a new strategy: developing microbes and microbial products that specifically attack cancer cells. This book breaks new ground in emerging cancer treatment modalities by presenting recent advances in the use of microorganisms and viruses as well as their products in cancer therapy. Seventeen chapters review the application of live microorganisms, high and low molecular weight products derived from microorganisms, and microbial products fused to cancertargeting molecules. In addition, the book highlights the benefits of a multi-target approach to destroy cancer cells. Readers will not only discover the results and significance of basic and clinical research, but also encouraging results from clinical trials. Emerging Cancer Therapy is divided into three sections: With chapters written by leading pioneers in microbial, biotech, and cancer research, Emerging Cancer Therapy is recommended for biotechnologists, microbiologists, clinical oncologists, medicinal chemists, and biochemists. Readers will not only learn the tremendous potential of microbial and biotechnological approaches to cancer therapy, but also discover new directions of research for effective drug discovery and development.
Preface ix Contributors xi Part I Live/Attenuated Bacteria and Viruses as Anticancer Agents 1 1 Salmonella Typhimurium Mutants Selected to Grow Only in Tumors to Eradicate Them in Nude Mouse Models 3 2 The Use of Living Listeria Monocytogenes as an Active Immunotherapy for the Treatment of Cancer 13 3 Bacillus Calmette–Guerin (BCG) for Urothelial Carcinoma of the Bladder 49 4 Live Clostridia: A Powerful Tool in Tumor Biotherapy 71 5 Bifi dobacterium as a Delivery System of Functional Genes for Cancer Gene Therapy 99 6 Replication-Selective Viruses for the Treatment of Cancer 119 7 Engineering Herpes Simplex Virus for Cancer Oncolytic Virotherapy 141 Part II Bacterial Products as Anticancer Agents 179 8 Promiscuous Anticancer Drugs from Pathogenic Bacteria: Rational Versus Intelligent Drug Design 181 9 Arginine Deiminase and Cancer Therapy 199 10 Cytosine Deaminase/5-Fluorocytosine Molecular Cancer Chemotherapy 219 11 Bacterial Proteins against Metastasis 243 12 Pseudomonas Exotoxin A-Based Immunotoxins for Targeted Cancer Therapy 269 13 Denileukin Diftitox in Novel Cancer Therapy 289 14 The Application of Cationic Antimicrobial Peptides in Cancer Treatment: Laboratory Investigations and Clinical Potential 309 15 Prodiginines and Their Potential Utility as Proapoptotic Anticancer Agents 333 16 Farnesyltransferase Inhibitors of Microbial Origins in Cancer Therapy 367 17 The Use of RNA and CpG DNA as Nucleic Acid-Based Therapeutics 379 Part III Patents On Bacteria/Bacterial Products as Anticancer Agents 403 18 The Role and Importance of Intellectual Property Generation and Protection in Drug Development 405 Index 421
Robert M. Hoffman
John Rothman, Anu Wallecha, Paulo Cesar Maciag, Sandra Rivera, Vafa Shahabi, and Yvonne Paterson
Timothy P. Kresowik and Thomas S. Griffith
Lieve Van Mellaert, Ming Q Wei, and Jozef Anné
Geng-Feng Fu, Yan Yin, Bi Hu, and Gen-Xing Xu
Padma Sampath and Steve H. Thorne
Jason S. Buhrman, Tooba A. Cheema, and Giulia Fulci
Arsénio M. Fialho and Ananda M. Chakrabarty
Lynn Feun, M. Tien Kuo, Ming You, Chung Jing Wu, Medhi Wangpaichitr, and Niramol Savaraj
Sergey A. Kaliberov and Donald J. Buchsbaum
Anna Maria Elisabeth Walenkamp
Philipp Wolf and Ursula Elsässer-Beile
Lin-Chi Chen and Nam H. Dang
Ashley L. Hilchie and David W. Hoskin
Neil R. Williamson, Suresh Chawrai, Finian J. Leeper, and George P.C. Salmond
Jingxuan Pan and Sai-Ching Jim Yeung
Jörg Vollmer
Arsénio M. Fialho and Ananda M. Chakrabarty
Subject Areas: Biology, life sciences [PS]
