Electric Brain Signals
Foundations and Applications of Biophysical Modeling

Presents biophysical theory and computer code for modelling and interpreting extracellular electric and magnetic brain signals.

Geir Halnes (Author), Torbjørn V. Ness (Author), Solveig Næss (Author), Espen Hagen (Author), Klas H. Pettersen (Author), Gaute T. Einevoll (Author)

9781009018623, Cambridge University Press

Paperback / softback, published 6 June 2024

400 pages
24.3 x 16.8 x 2.1 cm, 0.7 kg

'This book is a fantastic resource for the computational neuroscience community and beyond. The introductory 'guide' is outstanding in its clarity and description for readers with a range of backgrounds. The presentation is rigorous and detailed with many mathematical equations, and yet readable and understandable, with many figures. The authors are to be commended for their clearly defined terminologies and presentation of complex concepts. A gem of a read for anyone wanting to develop an in-depth understanding of electrical brain recordings and models of them.' Frances K. Skinner, Krembil Brain Institute, University Health Network and University of Toronto, Toronto, Ontario, Canada

It is common to study the electric activity of neurons by measuring the electric potential in the extracellular space of the brain. However, interpreting such measurements requires knowledge of the biophysics underlying the electric signals. Written by leading experts in the field, this volume presents the biophysical foundations of the signals as well as results from long-term research into biophysics-based forward-modeling of extracellular brain signals. This includes applications using the open-source simulation tool LFPy, developed and provided by the authors. Starting with the physical theory of electricity in the brain, this book explains how this theory is used to simulate neuronal activity and the resulting extracellular potentials. Example applications of the theory to model representations of real neural systems are included throughout, making this an invaluable resource for students and scientists who wish to understand the brain through analysis of electric brain signals, using biophysics-based modeling.

Preface
Abbreviations
Reserved physical symbols and quantities
1. Introduction
2. Charges, currents, fields and potentials in the brain
3. Neural dynamics
4. Volume-conductor theory
5. Conductivity of brain tissue
6. Schemes for computing extracellular potentials
7. Spikes
8. Local Field Potentials (LFPs)
9. Electroencephalography (EEG)
10. Electrocorticography (ECoG)
11. Magnetoencephalography (MEG)
12. Diffusion potentials in brain tissue
13. Final comments and outlook
Appendix A frequency-dependent length constant
Appendix B derivation of the current-dipole approximation
Appendix C electric stimulation
Appendix D derivation of point-source equation for anisotropic medium
Appendix E statistical measures
Appendix F fourier-based analyses
Appendix G derivation of formulas for population signals
Appendix H equations for computing magnetic fields
Appendix I derivation of the MC+ED scheme
References
Index.

Subject Areas: Biophysics [PHVN]