Dynamics of Proteins and Nucleic Acids

This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids.

J. Andrew McCammon (Author), Stephen C. Harvey (Author)

9780521356527, Cambridge University Press

Paperback, published 29 April 1988

248 pages
22.9 x 15.2 x 1.4 cm, 0.37 kg

'This book will undoubtedly serve as a generally good introductory text for expert and non-expert alike.' The Times Higher Education Supplement

This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.

Preface
1. Introduction
2. Structure of proteins, nucleic acids, and their solvent surroundings
3. Dynamics of proteins, nucleic acids, and their solvent surroundings
4. Theoretical methods
5. Short time dynamics
6. Local structural transitions
7. Global structural changes
8. Dynamics of molecular associations
9. Recent developments and future directions
Appendices
References
Index.

Subject Areas: Biotechnology [TCB], Toxicology [non-medical PSBT]