Droplets of Life
Membrane-Less Organelles, Biomolecular Condensates, and Biological Liquid-Liquid Phase Separation

The go-to reference on Biomolecular Condensates and Liquid-Liquid Phase Separation in Biological Systems

Vladimir N Uversky (Edited by)

9780128239674

Paperback, published 11 November 2022

728 pages, 100 illustrations (50 in full color)
23.5 x 19 x 4.4 cm, 0.45 kg

Approx.714 pages

Part I: Introduction to Membrane-less Organelles and Biomolecular Condensates
1. Biophysical Principles of Liquid-Liquid Phase Separation
2. Major Structural Features of MLOs
3. Multiphase Complex Droplets
4. Biogenesis of MLOs and Protein Condensates
5. Techniques for the Detection and Analysis of LLPS and MLOs
6. LLPS and Origin of Life

Part II: Biology of Membrane-Less Organelles
1. Known Types of Membrane-Less Organelles and Biomolecular Condensates
2. Active Regulation Mechanisms
3. Control of Metabolic Pathways
4. Interactions and Interplay with Classical Membrane-Bound Organelles
5. LLPS and Chromatin Organization
6. MLOs and Cellular Fitness
7. Cellular Stress
8. Phase Separation in Bacteria
9. Phase Separation and Virus Replication Compartments

Part III: Pathological roles of LLPS
1. Neurodegenerative Diseases
2. Cancer
3. Cardiovascular Diseases
4. Infectious Diseases

Subject Areas: Cellular biology [cytology PSF]