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Discovery and Development of Antidiabetic Agents from Natural Products
Natural Product Drug Discovery
Reviews the medicinal chemistry and latest developments in the identification and chemical development of antidiabetic agents from natural sources
Goutam Brahmachari (Author)
9780128094501, Elsevier Science
Paperback, published 1 November 2016
332 pages
22.9 x 15.1 x 2.2 cm, 0.69 kg
Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics.
Chapter 1. Andrographolide: A Molecule of Antidiabetic Promise Chapter 2. Computer-Aided Discovery of Glycogen Phosphorylase Inhibitors Exploiting Natural Products Chapter 3. Identification and Extraction of Antidiabetic Antioxidants from Natural Sources Chapter 4. Glucose Transporter 4 Translocation Activators From Nature Chapter 5. Carbohydrate-Based Antidiabetic Agents From Nature Chapter 6. Recent Developments on the Antidiabetic Sesquiterpene Lactones and Their Semisynthetic Analogues Chapter 7. Prediction of Prediabetes and Its Prevention by Functional Food Compounds Chapter 8. Immunomodulators in Prophylaxis and Therapy of Type-1 Diabetes Chapter 9. ?-Glucosidase Enzyme Inhibitors From Natural Products Chapter 10. Treasures of Indigenous Indian Herbal Antidiabetics: An Overview
