Dedication and Acknowledgments, xi
List of Contributors, xiii

1 Phenotypic Expression and Clinical Course of Hypertrophic Cardiomyopathy, 1
Barry J. Maron, MD

2 Genetic Mutations that Remodel the Heart in Hypertrophic Cardiomyopathy, 37
Carolyn Y. Ho, MD and Christine E. Seidman, MD

3 Genetic Basis and Genotype–Phenotype Relationships in Familial Hypertrophic Cardiomyopathy, 67
Albert A. Hagège, MD, PhD, Ketty Schwartz, PhD, Michel Desnos, MD, and Lucie Carrier, PhD

4 Historical Perspective, Mechanism, and Clinical Significance of Left Ventricular Outflow Tract Obstruction in Hypertrophic Cardiomyopathy, 81
Martin S. Maron, MD, Iacopo Olivotto, MD, and Barry J. Maron, MD

5 Hypertrophic Cardiomyopathy with Latent (Provocable) Obstruction: Pathophysiology and Management, 95
E. Douglas Wigle, MD, Maria Eriksson, MD, PhD, Paul Rakowski, David Focsaneanu, Cairrine Sloggett, RN, Anna Woo, MD, and Harry Rakowski, MD

6 Pathophysiology and Clinical Consequences of Atrial Fibrillation in Hypertrophic Cardiomyopathy, 105
Iacopo Olivotto, MD, Barry J. Maron, MD, and Franco Cecchi, MD

7 Other Modes of Disability or Death Including Stroke, and Treatment Strategies, in Hypertrophic Cardiomyopathy, 121
Franco Cecchi, MD, Iacopo Olivotto, MD, and Barry J. Maron, MD

8 Disturbed Vascular Control in Hypertrophic Cardiomyopathy: Mechanisms and Clinical Significance, 132
Ross Campbell, BSc, Jayne A. Morris-Thurgood, PhD, and Michael P. Frenneaux, FRCP, FRACP

9 Clinical Significance of Diastolic Dysfunction and the Effect of Therapeutic Interventions, 147
Sandro Betocchi, MD and Raffaella Lombardi, MD

10 Value of Exercise Testing in Assessing Clinical State and Prognosis in Hypertrophic Cardiomyopathy, 158
Sanjay Sharma, MRCP, MD

11 Pathophysiology and Significance of Myocardial Ischemia in Hypertrophic Cardiomyopathy, 172
Rajesh Thaman, MBBS, MRCP, Bhavesh Sachdev, MBBS, MRCP, and Perry M. Elliott, MBBS, MD, MRCP

12 Hypertrophic Cardiomyopathy in Japan: Clinical, Morphologic and Genetic Expression, 185
Yoshinori Doi, MD, PhD, Hiroaki Kitaoka, MD, Nobuhiko Hitomi, MD, Naohito Yamasaki, MD, Yoshihisa Matsumura, MD, Takashi Furuno, MD, and Barry J. Maron, MD

13 Prevalence, Prevention and Treatment of Infective Endocarditis in Hypertrophic Cardiomyopathy, 195
Paolo Spirito, MD, Marco Piccininno, MD, and Camillo Autore, MD

14 Pharmacologic Treatment of Symptomatic Hypertrophic Cardiomyopathy, 200
Mark V. Sherrid, MD and Ivan Barac, MD

15 Obstructive Hypertrophic Cardiomyopathy: Results of Septal Myectomy, 220
Joseph A. Dearani, MD and Gordon K. Danielson, MD

16 United States Perspectives on the Role of Dual-Chamber Pacing in Patients with Hypertrophic Cardiomyopathy, 236
Paul Sorajja, MD, Steve R. Ommen, MD, and Rick A. Nishimura, MD

17 Dual-Chamber Pacing for Hypertrophic Obstructive Cardiomyopathy, 246
Xavier Jeanrenaud, MD and Lukas Kappenberger, MD

18 Alcohol Septal Ablation, 259
Hubert Seggewiss, MD, Angelos Rigopoulos, MD, Lothar Faber, MD, and Peer Ziemssen, MD

19 Alcohol Septal Ablation in the Treatment of Hypertrophic Obstructive Cardiomyopathy: A Seven-Year Experience, 279
Horst Kuhn, MD, Thorsten Lawrenz, MD, Frank Lieder, MD, Frank H. Gietzen, MD, Ludger Obergassel, MD, Claudia Strunk-Muller, MD, Berit Stolle, MD, and Christian H. Leuner, MD

20 Role of Septal Ablation in a Surgical Center, 297
Harry M. Lever, MD

21 Molecular and Clinical Tools for Sudden Death Risk Assessment in Hypertrophic Cardiomyopathy, 307
Asifa Quraishi, MB, MRCP, Mohammad S. Hamid, MB, MRCP, and William J. McKenna, MD, FRCP

22 Risk Stratification For Sudden Death in Hypertrophic Cardiomyopathy: Extreme Left Ventricular Hyptertrophy as a New Indicator of Risk, 319
Paolo Spirito, MD and Barry J. Maron, MD

23 Implantable Defibrillator for Prevention of Sudden Death in Hypertrophic Cardiomyopathy, 327
Barry J. Maron, MD, Win-Kuang Shen, MD, and Paolo Spirito, MD

24 Hypertrophic Cardiomyopathy and Other Causes of Sudden Death in the Trained Athlete: An Electrophysiologist Perspective on the Management of Benign and Not So Benign Arrhythmias, 345
N. A. Mark Estes III, MD, Paul J. Wang, MD, Munther K. Homoud, MD, and Mark S. Link, MD

25 The Athlete's Heart, ECG, and Differential Diagnosis with Hypertrophic Cardiomyopathy and Other Cardiomyopathies, 367
Antonio Pelliccia, MD and Barry J. Maron, MD

26 Importance of Congenital Coronary Artery Anomalies, 382
Cristina Basso, MD, PhD, Domenico Corrado, MD, and Gaetano Thiene, MD

27 Arrhythmogenic Right Ventricular Cardiomyopathy and Hypertrophic Cardiomyopathy: Identification with the Italian Preparticipation Athlete Screening Program, 393
Domenico Corrado, MD, Cristina Basso, MD, PhD, Maurizio Schiavon, MD, and Gaetano Thiene, MD

28 Cardiovascular Causes of Sudden Death, Preparticipation Screening, and Criteria for Disqualification in Young Athletes, 404
Barry J. Maron, MD

29 Sudden Death Due to Chest Blows (Commotio Cordis), 432
Mark S. Link, MD, N. A. Mark Estes III, MD, and Barry J. Maron, MD

30 Naturally Occurring Animal Models of Cardiovascular Disease Causing Premature Death, 448
Philip R. Fox, DVM

31 The Role of the Internet and Patient Support Groups for Those Living with Hypertrophic Cardiomyopathy, 473
Lisa Salberg

Afterword, 481
Robert Jon Pensack, MD

Index, 487