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Developmental and Fetal Origins of Differences in Monozygotic Twins
From Genetics to Environmental Factors
Provides in-depth analysis of developmental and fetal origins of differences in monozygotic twins
Alexandra Matias (Edited by), Isaac Blickstein (Edited by)
9780128200476
Paperback, published 15 May 2020
386 pages, 90 illustrations (20 in full color)
23.4 x 19 x 2.5 cm, 0.81 kg
Developmental and Fetal Origins of Differences in Monozygotic Twins: From Genetics to Environmental Factors examines the major causes of discordance in monozygotic twins, from genetic, to environmental influences, including discussions on the genetic, epigenetic, fetal and environmental factors. Twin differences discussed include malformations, deformations and disruptions secondary to inequitable division of the early embryo, chromosome and single gene mosaicism, Nonrandom X chromosome inactivation, mitochondrial heteroplasmy, epigenetic variation, and variable and inequitable blood supply, among other influences. Differences in hemoglobin levels, placentation and amniotic fluid are also examined, while full color images illustrate discordant anomalies and twin differences throughout.
1. Introduction 2. Biology of monozygotic twinning 3. Mechanisms of discordance in monozygotic twins: why and when? 4. Monozygotic twins in history: enlightenment by mythology and ethnography 5. Genetics and epigenetics differences in monozygotic twins: the vision of the geneticist 6. Heterokaryotypic monozygotic twins 7. Differences in placentation in monochorionic twin pregnancies 8. Differences in growth: selective intrauterine growth restriction in monochorionic twins 9. Hemoglobin differences at birth in monochorionic twins 10. Differences in amniotic fluid in MZ twins 11. Twin-reversed arterial perfusion sequence: different identical twins 12. Major discordant anomalies in monozygotic twins: management and outcome 13. Congenital heart disease in monozygotic twins 14. Spotting the differences in the first trimester of pregnancy in MZ twins: the issue of aneuploidies and TTTS screening 15. Noninvasive prenatal screening in twin pregnancies 16. A new way to look at multiples: the power of image 17. Differences in monozygotic twins: the implications of diet and intestinal microbioma 18. Differences in development in monozygotic twins 19. Monozygotic twins: a personal as well as a criminal and jurisdictional approach 20. Monozygotic twin differences in perceived age 21. The environmental differences between twins in utero and their importance for downstream development: a need for standardized monitoring in obstetric research 22. Future perspectives
Subject Areas: DNA & Genome [PSAK1], Genetics [non-medical PSAK]
