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Development of Therapeutic Agents Handbook
Shayne Cox Gad (Edited by), SC Gad (Author)
9780471213857, Wiley
Hardback, published 6 January 2012
680 pages
28.7 x 22.5 x 5.4 cm, 2.894 kg
“The text is well-written and includes extensive references.” (Book News, 1 April 2012)
A comprehensive look at current drug discovery and development methods—and the roadmap for the future Providing both understanding and guidance in characterizing potential drugs and their production and synthesis, Development of Therapeutic Agents Handbook gives professionals a basic tool to facilitate research and development within this challenging process. This comprehensive text brings together, in one resource, a compendium of concepts, approaches, methodologies, and limitations that need to be considered in the formulation of therapeutic agents across a range of therapeutic fields. Both a reference and a call to action for the pharmaceutical industry, Development of Therapeutic Agents Handbook examines recent innovations taking shape in the various medical disciplines involved in drug discovery, and shows why these advances need to be embraced universally among researchers to improve their solution strategies. Additional subject matter includes: Extensive coverage and in-depth look into novel treatments and therapeutics Discussion of hot topics like new drugs and nutraceuticals, the discovery and development of vaccines, cancer therapeutics, and market overviews Coverage of therapeutic drug development for specific disease areas, such as cardiology, oncology, breast cancer, and kidney diseases As research in biology, chemistry, medicine, and technology rapidly progresses, it is becoming increasingly important for medical researchers to maintain an up-to-date knowledge base of emerging trends directing promising new therapies. Development of Therapeutic Agents Handbook serves this purpose, acting as both a one-stop reference rich in valid science, and a tool to carve out new pathways in the pursuit of bringing safer and more effective drugs to the marketplace.
PREFACE ix CONTRIBUTORS xi PART I FUNDAMENTAL CONCEPTS 1 1. Current Needs for New Therapeutic Agents and Discovery Strategies—A Systems Pharmacology Approach 3 2. Target Selection in Drug Discovery 25 3. New Drug Applications 35 4. From Concept to the Clinics: Development of Cancer Therapeutics 47 5. Development of Countermeasures for Bioterrorism in the United States 73 6. Development and Application of Conformation-Selective Integrin Antibodies 91 7. Pain Management Market Overview 113 8. Antiviral Market Overview 127 PART II METHODS AND TECHNIQUES IN DRUG DISCOVERY AND DEVELOPMENT 145 9. High-Throughput Screening for Small-Molecule Drug Discovery 147 10. Mass Spectrometry 181 11. Molecular Screening for Therapeutic Agents 207 12. Accelerator Mass Spectrometry and Positron Emission Tomography in Human Microdosing 241 13. Development of Antimicrobial Peptides as Therapeutic Agents 285 14. Antibodies for Human Diseases 359 15. Combinatorial Compounds and Drug Discovery 399 16. Locoregional Chemoradiotherapy of Cancer Using Hydrogel 413 17. RNAi-Mediated Therapeutics 425 18. Crystallography 445 19. PEGylation 463 20. Gold Standard Animal Models 517 21. Discovery of Vaccine Adjuvants 533 22. Oral Delivery of Macromolecules for the Development of Therapeutic Agents 547 23. Aerosol Drug Delivery to the Lungs 565 24. Resistance to Antiplatelet Theraphy 589 25. Antibiotic Development 611 PART III THERAPEUTIC TOPICS 629 26. Antimicrobial Resistance in Biofi lms: A Sticky Situation 631 27. Drotrecogin Alfa Activated (Recombinant Human Activated Protein C, Xigris) 645 28. Anti-Inflammatory Therapeutics 655 29. Anti-Inflammatory/Analgesics: An In-depth Look at p38 MAP Kinases 673 30. Cardiovascular Disease: In-Depth Look 707 31. Ezetimibe and Cholesterol Absorption 723 32. Cardiology—In-Depth Look: Kinases as Therapeutic Targets in the Heart 743 33. Statins in the Reduction of Cardiovascular Events 773 34. Cardiology—In-Depth Look: Advances in Antiplatelet Theraphy 785 35. Gastrointestinal Disorders: A Focus on Acid-Suppressive Agents 813 36. Pharmacology of Vasopressin and the Renin—Angiotension—Aldosterone System 825 37. New Drugs and Nutaceutical in the Treatment of Osteoarthristis 847 38. Development of Anticytokine Agents for Rheumatoid Arthritis 881 39. Overview of CNS Neuropharmaceuticals 897 40. Thinking Outside the Box in Alzheimer Disease Treatment 929 41. Neurotrophic Factors as Novel Therapeutic Targets 943 42. Oncology 963 43. Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia 999 44. Aromatase Inhibitors for Breast Cancer 1011 45. Evolution of Selective Estrogen and Androgen Receptor Modulators: Status of Current Therapy and New Drug Development 1019 46. In-Depth Look: anti-TNF-α Therapies 1045 47. Development of Therapeutic Agents: The Maternal—Fetal Perspective 1093 48. History of Antipsychotic Drug Development 1111 49. Radiopharmaceuticals and Medical Imaging: Development of Radioimmumoconjugates for Radioimmunoimaging and Radioimmunotherapy of Malignant Diseases 1137 50. Therapeutic Drug Development for Kidney Diseases 1159 51. Targeting Chemokines and Angiogenesis in Arthritis 1185 52. Development of Therapeutic Agents: Methods and Approaches in the Development of Vaccines against Protozoan Parasites 1207 53. Toxicology 1221 54. The Development of Phosphodiesterase 4 Inhibitors for Allergic and Nonallergic Infl ammatory Diseases of the Airways 1233 INDEX 1251
Sophie C. Desbiens and David H. Farb
Charles F. Albright
John S. McInnes and Donald O. Beers
Balveen Kaur, Gregory B. Lesinski, and Abhik Ray Chaudhary
Gregory H. Levine and Jeffrey I. Handwerker
Nathan S. Astrof, Dan Peer, and Motomu Shimaoka
Anita Holdcroft
Anita Arora, Natalia Mendoza, and Stephen K. Tyring
C. Parker and J.-H. Zhang
Robert D. English and Anthony M. Haag
R. Damoiseaux
Zhengdong Cheng
Robert S. Hodges, Ziqing Jiang, James Whitehurst, and Colin T. Mant
Guo-Liang Yu and Jian Ni
James C. Bigelow
David J. Yang, Ali Azhdarinia, Hiroaki Kurihara, and E. Edmund Kim
Nuria Morral and Scott R. Witting
Carl H. Schwalbe
Sanju Dhawan, Deepak N. Kapoor, Rishi Kapil, Mano Kumarj, and Ankur Bansal
Carol Casteneda and Michael S. LaPointe
Fiona A. Sharp and Ed C. Lavelle
Hye J. Lee and Chanmi Choi
Andrew R. Martin and Warren H. Finlay
Paul A. Gurbel, Udaya S. Tantry, and Mark J. Antonino
Robert L. Bettiker and Jason C. Gallagher
Shu Yeong Queck and Michael Otto
Byungse Suh and Rafi k Samuel
Marion M. Chan and Dunne Fong
Kelly L. Brown
Nicholas B. Norgard and Mazen Abu-Fadel
Stefan Oswald and Werner Siegmund
Karin Mauer and J. Emilio Exaire
Rajesh Sachdeva, Bradley Hughes, and Jawahar L. Mehta
Karin Mauer and Jorge F. Saucedo
Brian Hemstreet
Elizabeth J. Brant and Julian L. Seifter
Y. Henrotin and J. Y. Reginster
Jonathan Sherlock, Christopher D. Buckley, and Karim Raza
Tauser Roxana-Georgiana and Antohe Dan-Stefan
Rudy J. Castellani, Michael W. Marlatt, Akihiko Nunomura, Paula I. Moreira, Hyoung-Gon Lee, Gemma Casadesus, Xiogwei Zhu, George Perry, and Mark A, Smith
Stephen D. Skaper
Arkadiusz Z. Dudek and Steven F. Powell
Muhammad Mansoor Alam and Moshe Talpaz
Akm Hossain and Jame Abraham
Gregory T. Wurz and Michael W. DeGregorio
Satadal Chatterjee and Shobhan Gaddameedhi
C. Gedeon, F. Garcia Bournissen and G. Koren
Shankar S. Gollapudi and Rajan Radhakrishnan
Gang Niu and Xiaoyuan Chen
Mitchell H. Rosner, Joshua King, and Peter Monteleone
Zoltan Szekaneez and Alisa E Koch
Catherine Ivory and Kris Chadee
John H. Duffus
Mark A. Giembycz
Subject Areas: Chemistry [PN]
