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Developing Costimulatory Molecules for Immunotherapy of Diseases
Provides the latest information on the complex roles and interactions within the CD28 and B7 costimulatory families
Manzoor Ahmad Mir (Author)
9780128025857, Elsevier Science
Paperback, published 27 May 2015
322 pages
22.9 x 15.1 x 2.1 cm, 0.54 kg
"...a solid framework to understand costimulation and its role in selected diseases...best serves as a fundamental review of costimulation with clinical correlates for the basic-science researcher." --Annals of Allergy, Asthma & Immunology
Developing Costimulatory Molecules for Immunotherapy of Diseases highlights the novel concept of reverse costimulation and how it can be effectively exploited to develop immunotherapy using either humanized antibodies against CD80, CD86, and other costimulatory molecules or CD28 fusinogenic proteins in the treatment of diseases, including allergies, asthma, rheumatoid arthritis, multiple sclerosis, lupus nephritis, severe psoriasis, vulgaris tuberculosis, thopoid, transplantation therapeutic, cancer, and inflammation. The text aims to provide the latest information on the complex roles and interactions within the CD28 and B7 costimulatory families, with the hope that targeting these families will yield new therapies for the treatment of inflammation, autoimmunity, transplantation, cancer, and other infectious diseases.
Chapter 1: Introduction to costimulation and costimulatory molecules Chapter 2. Concept of reverse costimulation and its role in diseasesChapter 3. Costimulation immunotherapy in infectious diseasesChapter 4. Costimulation immunotherapy in allergies and asthmaChapter 5. Costimulation immunotherapy in lymphomas and cancerChapter 6. T cell costimulation and its applications in diseases
Subject Areas: Immunology [MJCM]
