Desk Encyclopedia of General Virology

A concise, comprehensive, and accessible guide to the principles and applications of virology

Marc H.V. van Regenmortel (Edited by), Brian W.J. Mahy (Edited by)

9780123751461, Elsevier Science

Hardback, published 2 September 2009

680 pages
27.8 x 21 x 3.6 cm, 2.09 kg

This volume, derived from Encyclopedia of Virology, provides an overview of the development of virology during the last ten years. Entries detail the nature, origin, phylogeny and evolution of viruses. It then moves into a summary of our understanding of the structure and assembly of virus particles and describes how this knowledge was obtained. Genetic material of viruses and the different mechanisms used by viruses to infect and replicate in their host cells are highlighted. The volume is rounded out with an overview of some major groups of viruses with particular attention being given to our current knowledge of their molecular biology.

Section 1. GENERAL TOPICS
History of virology: bacteriophages
History of virology: plant viruses
History of virology: vertebrate viruses
Nature of viruses
Origin of viruses
Ribozymes
Virus species
Quasispecies
Virus databases
Phylogeny of viruses
Evolution of viruses
Taxonomy, classification and nomenclature of viruses
Virus classification by pairwise sequence comparison
Prions of vertebrates
Viruses and bioterrorism

Section 2. VIRIONS
Principles of virion structure
Structure of non-enveloped virions
Electron microscopy of viruses
Cryo-electron microcopy
Assembly of non-enveloped virions
Assembly of enveloped virions
Assembly of bacterial viruses
Genome packaging of bacterial viruses
Viral membranes
Mimivirus

Section 3. NUCLEIC ACIDS
Recombination
Satellite nucleic acids and viruses
Retrotransposons of vertebrates
Defective interfering viruses
Interfering RNAs
Viruses as vectors in gene therapy

Section 4. VIRUS INFECTION
Viral receptors
Virus entry to bacterial cells
Membrane fusion
Replication of viruses
Persistent and latent viral infection
Apoptosis and virus infection
Viral pathogenesis
Antiviral agents
Diagnosis using serological and molecular approaches
Diagnosis using microarrays
Disease surveillance

Section 5. IMMUNE RESPONSES
Innate immunity
Defeating innate immunity
Antigen presentation
Antigenicity and immunogenicity of viral proteins
Cytokines and chemokines
Cell-mediated immunity to viruses
Antibody - mediated immunity to viruses
Orthomyxovirus antigen structure
Antigenic variation
Vaccine strategies
DNA Vaccines
Vaccine safety
Neutralization of infectivity
Immunopathology

Section 6. DESCRIPTION AND MOLECULAR BIOLOGY OF SOME VIRUSES
Adenoviruses : molecular biology
Baculoviruses : molecular biology of granuloviruses
Baculoviruses : molecular biology of nucleopolyhedroviruses
Coronaviruses : molecular biology
Hepatitis virus B : molecular biology
Herpes simplex viruses : molecular biology
Human cytomegalovirus : molecular biology
Human immunodeficiency viruses : molecular biology
Iridoviruses
Kaposi’s sarcoma-associated herpesvirus : molecular biology
Mononegavirales
Nidovirales
Nodaviruses
Orthomyxoviruses: molecular biology
Papillomaviruses: molecular biology
Partitiviruses
Phycodnaviruses
Picornaviruses
Reoviruses: molecular biology
Seadornaviruses
Tetraviruses
Togaviruses: molecular biology

Subject Areas: Virology [non-medical PSGL], Medical microbiology & virology [MMFM], Reference works [GBC]