Dementia with Lewy Bodies
Clinical, Pathological, and Treatment Issues

The first book devoted to the clinical, diagnostic and neuropathological features of dementia with Lewy bodies.

Robert Perry (Edited by), Ian McKeith (Edited by), Elaine Perry (Edited by), Jeffrey L. Cummings (Foreword by)

9780521561884, Cambridge University Press

Hardback, published 28 November 1996

541 pages, 53 b/w illus. 9 colour illus. 1 map 57 tables
23.5 x 15.8 x 3.4 cm, 0.905 kg

"...strongly recommended for clinical and basic investigators with interests in the broad field of neurodegeneration or those specifically working in the fields of behavioural neurology, neuropsychiatry, movement disorders and neuropharmacology." Anthony E. Lang, Canadian Journal of Neurological Sciences

Dementia with Lewy bodies (DLB) is perhaps the second most common cause of degenerative dementia after Alzheimer's disease. This book, which represents the first authoritative statement about DLB, arises from a workshop held in Newcastle, England, in October 1995, which brought together leading investigators with clinical and research experience of this condition. It includes review articles, case studies and recent research findings from the main centres studying DLB. Covering the classification, cognitive manifestations, clinical diagnosis, epidemiology, genetics, neuropathology, neurochemistry and treatment of DLB, this is a landmark publication in clinical neuroscience. It presents new operational criteria for research on DLB, and will interest all concerned with the problem of dementia in the elderly.

1. Introduction
Part I. Clinical Issues: 2. The clinical diagnosis and misdiagnosis of Lewy body dementia
3. The nosological status of Lewy body dementia
4. Putative clinical and genetic antecedents of dementia associated with Parkinson's disease
5. Clinical features of patients with Alzheimer's disease and Lewy bodies
6. The nature of the cognitive decline in Lewy body dementia
7. Non-cognitive symptoms in Lewy body dementia
8. Hallucinations, cortical Lewy body pathology, cognitive function and neuroleptic use in dementia
9. Neuropsychological aspects of Lewy body dementia
10. The neuroanatomical basis of cognitive deficits in Lewy body dementia
11. The clinical and functional imaging characteristics of Parkinsonian-dementia
12. Positron emission tomography findings in Parkinson's disease and Lewy body dementia
13. Clinical features of diffuse Lewy body disease in the elderly: analysis of 12 cases
14. Senile dementia of Lewy body type - clinical features and prevalence in neuropathological postmortems
15. Lewy body dementia in clinical practice
resume of clinical workshop sessions
Part II. Pathological Issues: 16. Pathological significance of Lewy bodies in dementia
17. Tautological tangles in neuropathologic criteria for dementias associated with Lewy bodies
18. What is the neuropathological basis of dementia associated with Lewy bodies?
19. Cytoskeletal and Alzheimer-type pathology in Lewy body disease
20. Diffuse Lewy body disease within the spectrum of Lewy body disease
21. Temporal lobe immunohistochemical pathology for tangles, plaques and Lewy bodies in diffuse Lewy body disease, Parkinson's disease and senile dementia of Alzheimer type
22. Pathological and clinical features of Parkinson's disease with and without dementia
23. Dementia with Lewy bodies: relationship to Parkinson's and Alzheimer's diseases
24. What do Lewy bodies tell us about dementia and Parkinsonism?
25. Pathogenesis of the Lewy body
26. Altered tau processing: its role in development of dementia in Alzheimer's disease and Lewy body disease
27. Cytoskeletal pathology in Alzheimer's disease and Lewy body dementia - an epiphenomenon?
28. Genetic correlations in Lewy body disease
resume of pathological workshop sessions
Part III. Treatment Issues: 29. Psychopharmacology of cognitive impairment in Parkinson's disease
30. Management of the non-cognitive symptoms of Lewy body dementia
31. Altered consciousness and transmitter signalling in Lewy body dementia
32. Cholinergic therapy and Lewy body dementia
33. Clinical heterogeneity in dementia
responders to cholinergic therapy
34. Tacrine and symptomatic treatment in Lewy body dementia
35. Neurochemical correlates of pathological and iatrogenic extrapyramidal symptoms
36. Neurotrophins and the cholinergic system in dementia
37. Relevance of Lewy bodies to alterations in oxidative stress in Lewy body dementia and Parkinson's disease
Resume of treatment workshop Sessions
Appendix.

Subject Areas: Psychiatry [MMH]