Freshly Printed - allow 10 days lead
Couldn't load pickup availability
Computer-Aided Vaccine Design
Joo Chuan Tong (Author), Shoba Ranganathan (Author)
9781907568411, Elsevier Science
Hardback, published 31 July 2013
164 pages
23.3 x 15.6 x 1.8 cm, 0.41 kg
Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.
List of figures List of abbreviations About the authors Preface Chapter 1: MHC and T cell responses Abstract: 1.1 Genetic organization of the MHC 1.2 MHC structure 1.3 MHC function 1.4 Peptide binding Chapter 2: Immunoglobulins and B cell responses Abstract: 2.1 Types of immunoglobulins 2.2 Immunoglobulin structure 2.3 Immunoglobulin function 2.4 Antigen binding Chapter 3: Scientific publications and databases Abstract: 3.1 Bibliographical information 3.2 Searching the literature 3.3 General databases containing information on genes and proteins 3.4 Immunological databases 3.5 Small molecule databases Chapter 4: Database design Abstract: 4.1 Fundamentals of database design 4.2 ER diagram 4.3 Normalization and normal forms Chapter 5: Computational T cell vaccine design Abstract: 5.1 Sequence-based methods 5.2 Structure-based methods 5.3 Broad-based T cell vaccine design Chapter 6: Computational B cell vaccine design Abstract: 6.1 Sequence-based methods 6.2 Structure-based methods Chapter 7: Infectious disease informatics Abstract: 7.1 Infectious diseases in history 7.2 Microbial sequence analysis 7.3 Detecting natural selection in molecular evolution Chapter 8: Vaccine safety and quality assessments Abstract: 8.1 Assessment of ADME/Tox deficiencies 8.2 Assessment of allergenicity Chapter 9: Vaccine adjuvant informatics Abstract: 9.1 Virtual combinatorial library 9.2 Chemical file formats 9.3 Considerations for virtual library design Index
Subject Areas: Immunology [MJCM]
