Combinatorial Chemistry and Molecular Diversity in Drug Discovery

Eric M. Gordon (Edited by), EM Gordon (Author), James F. Kerwin (Edited by)

9780471155188, Wiley

Hardback, published 15 September 1998

544 pages
23.8 x 16.4 x 3.1 cm, 0.903 kg

"This monograph does an excellent job summarizing many of the important aspects regarding the synthesis, manipulation, and screening of combinatorial molecules for pharmacological activity...The editors are to be commended on assembling an admirable resource..." (The Quarterly Review of Biology Vol. 76, No. 2, June 2001)

Ein hochaktueller Überblick über die neuen Forschungsrichtungen der molekularen Vielfalt und kombinatorischen Chemie, von denen man umfangreiche Auswirkungen auf Pharmazie und Wirkstofforschung erwartet, wie z. B. die Einsparung von Zeit und Kosten. Diskutiert werden relevante Techniken und Hilfsmittel sowie organisatorische und strategische Fragen, mit denen Manager bei Umsetzung und Ausnutzung kombinatorischer Verfahren konfrontiert werden. (06/98)

COMBINATORIAL CHEMISTRY AND MOLECULAR DIVERSITY: AN INTRODUCTION.

Historical Overview of the Developing Field of Molecular Diversity (J. Chabala, et al.).

Solid-Phase Peptide Synthesis, Lead Generation, and Optimization (B. Seligman, et al.).

Oligonucleotide Libraries as a Source of Molecular Diversity (H.-Y. Mei, et al.).

SMALL MOLECULAR LIBRARIES.

Protease Inhibitor Libraries (D. Patel & D. Campbell).

Scaffolds for Small Molecule Libraries (M. Pavia).

Encoded Combinatorial Chemistry (J. Jacobs & Z.-J. Ni).

Parallel Organic Synthesis in Array Format (S. Hall).

AUTOMATION, ANALYTICAL, AND COMPUTATIONAL METHODS.

Automation of Combinatorial Chemistry for Large Libraries (M. Needels & J. Sugarman).

Quantifying Diversity (Y. Martin, et al.).

BIOLOGICAL DIVERSITY.

Protein Scaffolds for Peptide Libraries (R. Hoess).

SCREENING.

Strategies for Screening Combinatorial Libraries (B. Beutel).

COMBINATORIAL DRUG SCREENING AND DEVELOPMENT.

Combinatorial Technologies: Prospects and Future Issues (J. Kerwin).

Appendix.

Index.

Subject Areas: Chemistry [PN]