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Clusterin
Cutting-edge research and up-to-date findings on clusterin, written by leaders in the field
Saverio Bettuzzi (Volume editor), Sabina Pucci (Volume editor)
9780123747723, Elsevier Science
Hardback, published 23 November 2009
350 pages
22.9 x 15.1 x 2.5 cm, 0.59 kg
"This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences." -- American Scientist "Excellent, highly informative, in-depth reviews...expertly written, up-to-date, and well-referenced." -- Journal of Medicinal Chemistry "This is a series that has a long tradition of excellence in the field of cancer biology." -- Doody's Publishing Reviews
The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass of information of tremendous biological importance that are teaching us an important lesson in molecular biology of gene expression regulation. This volume brings together the contributions of top researchers in the field, providing an overview and synthesis of the latest thought and findings relating to CLU.
. Introduction Saverio Bettuzzi 2. Clusterin (CLU): From One Gene and Two Transcripts to Many Proteins Federica Rizzi, Mariangela Coletta, and Saverio Bettuzzi 3. The Shifting Balance Between CLU Forms During Tumor Progression Sabina Pucci and Saverio Bettuzzi 4. Regulation of Clusterin Activity by Calcium Beata Pajak and Arkadiusz Orzechowski 5. Nuclear CLU (nCLU) and the Fate of the Cell Saverio Bettuzzi and Federica Rizzi 6. The Chaperone Action of Clusterin and Its Putative Role in Quality Control of Extracellular Protein Folding Amy Wyatt, Justin Yerbury, Stephen Poon, Rebecca Dabbs, and Mark Wilson 7. Cell Protective Functions of Secretory Clusterin (sCLU) Gerd Klocks, Markus Baiersdo¨ rfer, and Claudia Koch-Brandt 8. Clusterin: A Multifacet Protein at the Crossroad of Inflammation and Autoimmunity Ge´ raldine Falgarone and Gilles Chiocchia 9. Oxidative Stress in Malignant Progression: The Role of Clusterin, A Sensitive Cellular Biosensor of Free Radicals Ioannis P. Trougakos and Efstathios S. Gonos
Subject Areas: Molecular biology [PSD], Biochemistry [PSB], Biophysics [PHVN], Oncology [MJCL], Medical research [MBGR]
