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Clostridial Diseases of Animals

Francisco A. Uzal (Edited by), FA Uzal (Author), Bruce A. McClane (Edited by), Iman Mehdizadeh Gohari (Edited by), Mauricio A. Navarro (Edited by), Michel R. Popoff (Edited by)

9781394210145, Wiley

Hardback, published 11 June 2026

512 pages
25.6 x 18.3 x 2.8 cm, 1.225 kg

Comprehensive and up-to-date coverage of clostridial diseases

The newly revised second edition of Clostridial Diseases of Animals is a timely update to the gold-standard resource for veterinary practitioners treating clostridial disease in animals. This is a comprehensive, detailed reference that emphasizes clinically relevant information on pathogenesis, pathology, microbiology, diagnostic techniques, clinical management, and treatment.

The Second Edition takes a new One Health perspective, offering brand-new chapters that cover enteric, histotoxic, and neurotoxic clostridial diseases in animals and humans. The book also explores the reclassification of C. perfringens, providing references throughout to explain the level of evidence supporting each conclusion.

Inside the book:

  • A thorough treatment of clostridial diseases with accurate coverage of new information and technologies
  • A reorganized gastrointestinal section reflecting the changes to the classification of C. perfringens
  • Practical discussions of enteric, histotoxic, and neurotoxic clostridial diseases
  • Fully cited references demonstrating the evidence base

Written for veterinary clinicians, diagnosticians, pathologists, and microbiologists, Clostridial Diseases of Animals will also benefit regulators working in government agencies with a stake in this issue, as well as veterinary students.

List of contributors xix

Preface xxiii

Part I The pathogenic clostridia 1

1 Taxonomic relationships among the clostridia 3
Paul A. Lawson

2 General physiological and virulence properties of the pathogenic clostridia 9
Julian I. Rood

3 Brief description of animal pathogenic clostridia 15
Iman Mehdizadeh Gohari

Part II Toxins produced by the pathogenic clostridia 25

4 Toxins of histotoxic clostridia: Clostridium chauvoei, Clostridium septicum, Clostridium novyi, Paraclostridium sordellii, Clostridium histolyticum 27
Michel R. Popoff

5 Toxins of Clostridium perfringens 67
James R. Theoret, Iman Mehdizadeh Gohari, and Bruce A. McClane

6 Toxins of Clostridioides difficile 83
Panagiotis Papatheodorou

7 Clostridium botulinum and Clostridium tetani neurotoxins 95
Michel R. Popoff

Part III Clostridial infections of the gastrointestinal system 163

8 Diseases produced by Clostridium perfringens type A in animals 165
Francisco A. Uzal and Mauricio A. Navarro

9 Infections by Clostridium perfringens type B 175
Francisco A. Uzal and John S. Munday

10 Diseases produced by clostridium perfringens type c 183
Santiago S. Diab and Horst Posthaus

11 diseases produced by Clostridium perfringens type d 199
Francisco A. Uzal, Federico Giannitti, John W. Finnie, and Jorge P. García

12 Diseases produced by Clostridium perfringens type E 219
Mauricio A. Navarro and Francisco A. Uzal

13 Clostridium perfringens type F infections of animals 223
Iman Mehdizadeh Gohari and Bruce A. McClane

14 Diseases produced by Clostridium perfringens type G 231
Kerry K. Cooper and Margarethe A. Cooper

15 Diseases produced by Clostridioides difficile 267
Santiago S. Diab and Francisco A. Uzal

16 Disease caused by Clostridium colinum: ulcerative enteritis of poultry and other avian species 291
Agustin Rebollada-Merino and Francisco A. Uzal

17 Diseases produced by Thomasclavelia spiroformis 301
Laura M. Tuomisto and Francisco A. Uzal

18 Clostridial abomasitis 309
John F. Prescott and Russell S. Fraser

Part IV Clostridial histotoxic infections 325

19 Blackleg 327
Camila C. Abreu and Francisco A. Uzal

20 Gas gangrene 345
Rodrigo O. S. Silva, Francisco A. Uzal, Carlos A. Oliveira Junior, and Francisco C. F. Lobato

21 Gangrenous dermatitis in poultry 359
Mauricio A. Navarro, Francisco A. Uzal, and H. L. Shivaprasad

22 Bacillary hemoglobinuria 369
Mauricio A. Navarro, Fernando Dutra-Quintela, and Francisco A. Uzal

23 Infectious necrotic hepatitis 381
Mauricio A. Navarro and Francisco A. Uzal

24 Tyzzer disease 387
Karina C. Fresneda, Juan A. García, and Francisco R. Carvallo-Chaigneau

Part V Clostridial neurotoxic infections 401

25 Tetanus 403
Michel R. Popoff and Francisco A. Uzal

26 Botulism 415
Caroline Le Maréchal, Fabrizio Anniballi, Luca Bano, Martin B. Dorner, Miriam Koene, Christelle Mazuet, Christian Seyboldt, and Tom Van Nieuwenhuysen

27 Diseases caused by other clostridia producing neurotoxins 451
John F. Prescott and Michel R. Popoff

Part VI Animal clostridial diseases as zoonosis and animals as reservoir of human clostridial pathogens 455

28 Clostridial infections and one health 457
Francisco A. Uzal and Michel R. Popoff

Index 475

Subject Areas: Veterinary medicine [MZ]
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