Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

An extensive reference on the disease-modifying chemical leads and drugs that exist for neurodegenerative diseases, with a focus on Alzheimer’s, tauopathies, and other misfolding diseases

Pierfausto Seneci (Author)

9780128019443, Elsevier Science

Hardback, published 14 January 2015

260 pages
22.9 x 15.1 x 2.2 cm, 0.53 kg

This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer’s and other tauopathies. Properties and development status of these molecular targets and disease mechanisms are thoroughly described, as are small molecule effectors of autophagy and dis-aggregating agents.

Chapter 1 Chemical modulators of protein misfolding, neurodegeneration and tau: What’s not covered nextChapter 2 Targeting the protein quality control (PQC) machinery: Chaperones & Co...Chapter 3 Targeting proteasomal degradation of soluble, misfolded proteins: Ubi majorChapter 4 Targeting unselective autophagy of cellular aggregates: A shotgun approachChapter 5 Targeting selective autophagy of insoluble protein aggregates: The sniper’s philosophyChapter 6 Targeting assembly and disassembly of protein aggregates: A raggle-taggle bunch with high hopes

Subject Areas: Molecular biology [PSD], Pharmacology [MMG], Neurology & clinical neurophysiology [MJN]