Chemical Biophysics
Quantitative Analysis of Cellular Systems

Was the first textbook to apply rigorous physical chemistry principles to mathematical and computational modelling of biochemical systems.

Daniel A. Beard (Author), Hong Qian (Author)

9780521158244, Cambridge University Press

Paperback, published 25 November 2010

330 pages
24.4 x 17 x 1.7 cm, 0.53 kg

Review of the hardback: 'It is recommended for institutional or personal purchase as it comprises a substantial reference textbook.' Microbiology Today

Chemical Biophysics provides an engineering-based approach to biochemical system analysis for graduate-level courses on systems biology, computational bioengineering and molecular biophysics. It is the first textbook to apply rigorous physical chemistry principles to mathematical and computational modeling of biochemical systems for an interdisciplinary audience. The book is structured to show the student the basic biophysical concepts before applying this theory to computational modeling and analysis, building up to advanced topics and research. Topics explored include the kinetics of nonequilibrium open biological systems, enzyme mediated reactions, metabolic networks, biological transport processes, large-scale biochemical networks and stochastic processes in biochemical systems. End-of-chapter exercises range from confidence-building calculations to computational simulation projects.

Preface
Introduction
Part I. Background Material: 1. Concepts from physical chemistry
2. Conventions and calculations for biochemical systems
3. Chemical kinetics and transport processes
Part II. Analysis and Modeling of Biochemical Systems: 4. Enzyme-catalyzed reactions
5. Biochemical signaling modules
6. Biochemical reaction networks
7. Coupled biochemical systems and membrane transport
Part III. Special Topics: 8. Spatially distributed systems and reaction-diffusion modeling
9. Constraint-based analysis of biochemical systems
10. Biomacromolecular structure and molecular association
11. Stochastic biochemical systems and the chemical master equation
12. Appendix: the statistical basis of thermodynamics
Bibliography
Index.

Subject Areas: Biochemical engineering [TC], Molecular biology [PSD], Biochemistry [PSB], Biophysics [PHVN]